Effects of Atrial Natriuretic Peptide on Glycerol Induced Acute Renal Failure in the Rat.

スポンサーリンク

概要

• 論文の詳細を見る

• Acute and chronic experiments were performed in rats to examine whether atrial natriuretic peptide (ANP) has any beneficial effects on glycerol-induced acute renal failure (ARF). ANP infusion (Atriopeptin III, 1.0μg/kg+0.2μg/kg/min) improved the renal blood flow (RBF) and the glomerular filtration rate (GFR), and induced profound natriuresis in the early stage of ARF. By contrast, ANP decreased RBF in the control rats. In addition to these acute hemodynamic effects, long-term beneficial effects of ANP were also observed. A 75-min infusion of ANP significantly lessened the degree of azotemia as well as the extent of renal histologic damage assessed 24 hours after the glycerol injection. These results indicate that ANP can afford partial protection against both acute renal dysfunction and the chronic course of the glycerol-induced ARF, suggesting that ANP may be useful in the treatment of ARF.

• International Heart Journal刊行会の論文

著者

• KUROKAWA Kiyoshi

  First Department of Internal Medicine, Faculty of Medicine, University of Tokyo

• AIZAWA Chikara

  First Department of Internal Medicine, Faculty of Medicine, University of Tokyo

• SUZUKI Keiji

  First Department of Internal Medicine, Faculty of Medicine, University of Tokyo

• Kurokawa Kiyoshi

  First Department Of Internal Medicine Faculty Of Medicine University Of Tokyo

• SEKI George

  First Department of Internal Medicine, Faculty of Medicine, University of Tokyo

• NONAKA Tatsuya

  First Department of Internal Medicine, Faculty of Medicine, University of Tokyo

• NOSAKA Kazuo

  First Department of Internal Medicine, Faculty of Medicine, University of Tokyo

• TANIGUCHI Shigeo

  First Department of Internal Medicine, Faculty of Medicine, University of Tokyo

関連論文

• Growth of fetal rat gastro-intestinal epithelial cells is region-specifically controlled by growth factors and substrata in primary culture
• One-point quantitative determination of pretreatment serum hepatitis C virus RNA predicts long-term responsiveness to high-dose interferon therapy
• -1211-STRETCH MAY ENHANCE THE RELEASE OF ENDOTHELIUM-DERIVED RELAXING FACTOR IN RABBIT AORTA : THE 54th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY
• Protection from D-galactosamine-induced liver injury by orally active novel peptide leukotriene receptor antagonist, ONO-1078
• Suppression of humoral immunity by monoclonal antibody to CD79b, an invariant component of antigen receptors on B lymphocytes
• Depletion of the Renal Medullary Osmotic Gradient Following Hemorrhagic Hypotension in Hydropenic Rabbits
• Effects of Indomethacin on Renal Hemodynamic Alterations Caused by Arterial and Ureteral Pressure Changes in Rabbits
• Large spleno-caval shunt not accompanied by cirrhosis or encephalopathy
• Renal Hemodynaniics and Medullary Osmolal Gradient in Ischemic Acute Renal Failure in Rabbits
• Alterations in the Intrarenal Hemodynamics Following Changes in Ureteral Pressure in the Rabbit Kidney
• Effects of Atrial Natriuretic Peptide on Glycerol Induced Acute Renal Failure in the Rat.

もっと見る 閉じる

スポンサーリンク