Effects of Indomethacin on Renal Hemodynamic Alterations Caused by Arterial and Ureteral Pressure Changes in Rabbits

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概要

• 論文の詳細を見る

• Roles of prostaglandins in renal autoregulation and the distribution of cortical blood flow were studied in anesthetized rabbits, by means of prostaglandin synthesis inhibition. Within the range from 80 to 130mmHg in renal perfusion pressure, a constancy of renal blood flow was maintained. With an abrupt elevation of perfusion pressure from 100 to 130mmHg, blood flow did not alter in any regions of the cortex. In contrast, when perfusion pressure was reduced from 100 to 80mmHg, blood flow decreased in the outer cortex with reciprocal increase in the inner cortex. These hemodynamic changes were not affected by indomethacin. Acute ureteral pressure elevation to 50mmHg resulted in a redistribution of cortical flow to the inner cortex without significant change in renal blood flow. This redistribution was inhibited by indomethacin. During ureteral pressure elevation, autoregulation was impaired. In this situation, a rise of perfusion pressure produced a significant increase in blood flow in the outer cortex without significant change elsewhere. A reduction of perfusion pressure gave rise to significant decrease in flow in the outer cortex without an increase in the inner cortex. In indomethacin-treated rabbits, ureteral pressure elevation impaired autoregulation slightly but not significantly. These findings suggest 1) good autoregulatory capability in all regions of the renal cortex; and 2) a minor role of prostaglandins in the development of renal autoregulation in normal rabbits but a partial contribution to the impairment of autoregulation during ureteral pressure elevation.

• International Heart Journal刊行会の論文

著者

• AIZAWA Chikara

  First Department of Internal Medicine, Faculty of Medicine, University of Tokyo

• HONDA Nishio

  First Department of Internal Medicine, Faculty of Medicine, University of Tokyo

関連論文

• Depletion of the Renal Medullary Osmotic Gradient Following Hemorrhagic Hypotension in Hydropenic Rabbits
• Effects of Indomethacin on Renal Hemodynamic Alterations Caused by Arterial and Ureteral Pressure Changes in Rabbits
• Renal Hemodynaniics and Medullary Osmolal Gradient in Ischemic Acute Renal Failure in Rabbits
• Alterations in the Intrarenal Hemodynamics Following Changes in Ureteral Pressure in the Rabbit Kidney
• Alterations in the Renal Hemodynamics Induced by Increased Renal Vein Pressure in the Rabbit Kidney
• Effects of Atrial Natriuretic Peptide on Glycerol Induced Acute Renal Failure in the Rat.

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