Long-term observation of cardiac function in Duchenne's muscular dystrophy. Evaluation using systolic time intervals and echocardiography.:Evaluation Using Systolic Time Intervals and Echocardiography

スポンサーリンク

概要

• 論文の詳細を見る

• Cardiac involvement is common in patients with Duchenne type muscular dystrophy (DMD). However, published reports of long-term follow-up studies in the same patients are very rare. The purpose of this study was to clarify the natural course of cardiac dysfunction in DMD, and to analyze the relationship between the deterioration of cardiac function and skeletal muscular function.The cardiac function was serially evaluated for 2-12 years in 34 patients with DMD. The systolic time intervals and echocardiography were used for evaluating the cardiac function. The PEP/ET (pre-ejection period/ejection time) of systolic time intervals significantly deteriorated in 9-12 years (p<0.001). The maximal systolic and diastolic endocardial velocity (MSEV and MDEV) and the D/S ratio of echocardiography significantly deteriorated in 5 years (p<0.001). The D/S ratio is the ratio of the mean systolic velocity and the mean diastolic velocity of the left ventricular posterior wall.In almost half the patients, the deterioration of these parameters was correlated with that of Swinyard's stage. The Swinyard's functional ability stage demonstrates the grade of the skeletal muscular dysfunction. However, there was no correlation between the deterioration of cardiac function and Swinyard's stage in the other half of the patients. Correlation coefficient in the whole group was 0.32 (p=n.s.) between the PEP/ET and Swinyard's stage, and was -0.15 (p=n.s.) between the D/S ratio and Swinyard's stage. Although the mean left ventricular ejection fraction calculated using echocardiography was slightly decreased for 5 years, no significant change was detected in the whole group.One patient had progressive deterioration of left ventricular function despite mild skeletal muscular dysfunction, and died from congestive heart failure. The cardiac dysfunction was predominant. We named it'cardiac type' DMD.Since deterioration of cardiac function was not always correlated with deterioration of skeletal muscular function (Swinyard's stage), cardiac function must be carefully monitored in patients with DMD.

• International Heart Journal刊行会の論文

著者

• Matsuo Shuzo

  Cardiology Division, Department of Intenal Medicine, Saga Medical School

• UTSUNOMIYA Toshinori

  Third Department of Internal Medicine, Nagasaki University School of Medicine

• HASHIBA Kunitake

  Third Department of Internal Medicine and Central iagnostic Laboratory, Nagasaki University School of Medicine

• OKU Yasuhiko

  Third Department of Internal Medicine, Nagasaki University School of Medicine

• MORI Hideki

  Third Department of Internal Medicine, Nagasaki University School of Medicine

• SHIBUYA Noritoshi

  Kawatana National Hospital

• MATSUO Shuzo

  Cardiology Division, Saga Medical School

関連論文

• SCREENING OF CARDIAC β MYOSIN HEAVY CHAIN(MHC)GENES OF FAMILIAL HYPERTROPHIC CARDIOMYOPATHY(FHCM)IN JAPAN
• APACHE (Acute Physiology, Age, Chronic Health Evaluation) III score is a powerful predictor of 30-days mortality in acute heart failure
• An Elderly Man With Klinefelter Syndrome Associated With Hypertrophic Cardiomyopathy, Sick Sinus Syndrome, and Coronary Arteriovenous Fistula
• -P265- Assessment of Left Atrial Ejection Force in Patients with Heart Disease Using Pulsed Wave Doppler(PROCEEDINGS OF THE 59th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY)
• -0829- MENTAL ARITHMETIC STRESS TEST IS AN USEFUL INDUCER FOR ATTACK OF ANGINA PECTORIS(PROCEEDINGS OF THE 59th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY)
• THE INFLUENCE OF ADVANCING AGE ON THE ELECTROPHYSIOLOGICAL CHANGES OF THE ATRIAL MUSCLE INDUCED BY PROGRAMMED ATRIAL STIMULATION
• NEWLY SYNTHESIZED DIPEPTIDE RENIN INHIBITOR, KRI 1177 : EVALUATION OF RENIN INHIBITION AND BLOOD PRESSURE REDUCTION : Hypertension : PROCEEDINGS OF THE 50th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY
• Neurohumoral Factors in Borderline Hypertension : Borderline Hypertension
• DYNAMIC RESPONSES OF INACTIVE RENIN FOLLOWING ADMINISTRATION OF SQ14225 AND PROPRANOLOL : Hypertension : PROCEEDINGS OF THE 44th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY
• RELEASE OF ACTIVE AND INACITIVE BENIN BY THE HUMAN KIDNEY : Hypertension I : Ist Auditorium : Proceedings of the 43rd Annual Meeting of the Japanese Circulation Society, Tokyo, 1979
• -237-DYNAMIC RESPONSES OF ACTIVE AND INACTIVE RENIN AFTER LOADING OF FUROSEMIDE IN NORMAL AND HYPERTENSIVE SUBJECTS : Renin,Angiotensin : PROCEEDINGS OF THE 42nd ANNUAL MEETING OF THE JAPANESE CIRCULATION SOCIETY
• Superior and Inferior Vena Cava Flow Velocity in Patients with Anomalous Pulmonary Vein Connection
• Systolic Time Intervals in Progressive Muscular Dystrophy
• Correction of Hypertension by Partial Nephrectomy in Segmental Renal Artery Stenosis and Electron Microscopic Studies of Renin
• Primary Aldosteronism Aggravated during Peripartum Period
• Well-Controlled Comparative Study of the Clinical Effectiveness of Intravenous Mexiletine and Procainamide on Ventricular Premature Contraction
• Influences of Autonomic Changes on the Sinus Node Recovery Time in Patients with Sick Sinus Syndrome
• Calculation of Mitral Valve Area in Mitral Stenosis Using the Proximal Isovelocity Surface Area Method : Comparison with Two-Dimensional Planimetry and Doppler Pressure Half Time Method
• Abnormality of circulatory reflex and aldosterone response during head-up tilting in patients with primary aldosteronism.
• Sinus node function after selective elimination of sympathetic influences on the sinus node area of the dog.
• Angina Pectoris Caused by Dynamic Exercise in Hypertrophic Cardiomyopathy with Normal Coronary Arteries.
• Influence of collateral flow reduction on electrophysiologic properties of preexisting ischemic area and inducibility of ventricular arrhythmias in the dog.
• The relationship between 24 hour total heart beats or ventricular arrhythmias and cardiopulmonary function in patients with Duchenne's muscular dystrophy.
• Elevation of plasma renin activity during pregnancy and rupture of a dissecting aortic aneurysm in a patient with primary aldosteronism.
• Effects of combined changes in serum calcium and potassium on QT interva. A study by holter electrocardiographic monitoring during hemodialysis.:A Study by Holter Electrocardiographic Monitoring during Hemodialysis
• The role of renal kallikrein and prostaglandin in the control of renin release.
• The mechanism of the control of renin release by beta-adrenergic receptors.
• Conduction Properties of the Antegrade Fast and Slow AV Nodal Pathways Associated with AV Nodal Reentrant Tachycardia.
• Effects of chronic hypokalemia on ventricular vulnerability during acute myocardial ischemia in the dog.
• Production of Active and Inactive Renin by Adrenal Explant Cultures and the Existence of a Prorenin Activating Enzyme in the Adrenal Gland.
• Contracted Form of Primary Endocardial Fibroelastosis in a Young Adult without Congestive Heart Failure
• Effect of angiotensin III on blood pressure, renin-angiotensin-aldosterone system in normal and hypertensive subjects.
• Evaluation of Myocardial Damage in Duchenne's Muscular Dystrophy with Thallium-201 Myocardial SPECT.
• Long-term observation of cardiac function in Duchenne's muscular dystrophy. Evaluation using systolic time intervals and echocardiography.:Evaluation Using Systolic Time Intervals and Echocardiography
• Effects of Sympathetic and Parasympathetic Stimulation on the Induction of Atrial Flutter in Dogs with Aseptic Pericarditis.

もっと見る 閉じる

スポンサーリンク