The role of renal kallikrein and prostaglandin in the control of renin release.
スポンサーリンク
概要
- 論文の詳細を見る
Renal prostaglandins and kallikrein are considered to play an important role in the control of renin release. Recently, we have shown that aprotinin, a kallikrein inhibitor, inhibits the stimulation of plasma renin activity (PRA) by either furosemide or a low sodium diet. However, the mechanisms of action of kallikrein are unknown. Since kallikrein may stimulate bradykinin and prostaglandin production, the present study examines the relationship of renal kallikrein and renal prostaglandins in the control of renin release. Furosemide and a low sodium diet stimulated PRA, urinary kallikrein excretion and urinary prostaglandin E2 excretion. Aprotinin and indomethacin inhibited both furosemide and low sodium diet stimulation of PRA. When maximum doses of both aprotinin and indomethacin were given, PRA was more strongly suppressed than by indomethacin alone. The stimulation of urinary kallikrein excretion by furosemide and by a low sodium diet was not inhibited by indomethacin. These results suggest that both renal kallikrein and prostaglandins play an important role in the control of renin release under sodium depletion. Renal kallikrein may also have a direct action on the kidney to release renin.
- International Heart Journal刊行会の論文
著者
-
SUZUKI Shin
Third Department of Internal Medicine and Central iagnostic Laboratory, Nagasaki University School of Medicine
-
HASHIBA Kunitake
Third Department of Internal Medicine and Central iagnostic Laboratory, Nagasaki University School of Medicine
-
SUZUKI Shin
Third Department of Medicine, Nagasaki University School of Medicine
-
KOBAYASHI Masao
Third Department of Medicine, Nagasaki University School of Medicine
関連論文
- Influence of Mild to Moderate Obesity on Left Ventricular Stress Filling Pattern in Hypertension
- 0873 THE CORRELATION OF BLOOD PRESSURE BETWEEN SONS, DAUGHTERS, AND PARENTS BY THE MEASUREMENT OF HOME BLOOD PRESSURE FOR ONE : MONTH IN RURAL COMMUNITY IN SOUTHERN JAPAN
- THE INFLUENCE OF ADVANCING AGE ON THE ELECTROPHYSIOLOGICAL CHANGES OF THE ATRIAL MUSCLE INDUCED BY PROGRAMMED ATRIAL STIMULATION
- NEWLY SYNTHESIZED DIPEPTIDE RENIN INHIBITOR, KRI 1177 : EVALUATION OF RENIN INHIBITION AND BLOOD PRESSURE REDUCTION : Hypertension : PROCEEDINGS OF THE 50th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY
- Neurohumoral Factors in Borderline Hypertension : Borderline Hypertension
- DYNAMIC RESPONSES OF INACTIVE RENIN FOLLOWING ADMINISTRATION OF SQ14225 AND PROPRANOLOL : Hypertension : PROCEEDINGS OF THE 44th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY
- RELEASE OF ACTIVE AND INACITIVE BENIN BY THE HUMAN KIDNEY : Hypertension I : Ist Auditorium : Proceedings of the 43rd Annual Meeting of the Japanese Circulation Society, Tokyo, 1979
- -237-DYNAMIC RESPONSES OF ACTIVE AND INACTIVE RENIN AFTER LOADING OF FUROSEMIDE IN NORMAL AND HYPERTENSIVE SUBJECTS : Renin,Angiotensin : PROCEEDINGS OF THE 42nd ANNUAL MEETING OF THE JAPANESE CIRCULATION SOCIETY
- Superior and Inferior Vena Cava Flow Velocity in Patients with Anomalous Pulmonary Vein Connection
- Systolic Time Intervals in Progressive Muscular Dystrophy
- Correction of Hypertension by Partial Nephrectomy in Segmental Renal Artery Stenosis and Electron Microscopic Studies of Renin
- Primary Aldosteronism Aggravated during Peripartum Period
- Well-Controlled Comparative Study of the Clinical Effectiveness of Intravenous Mexiletine and Procainamide on Ventricular Premature Contraction
- Influences of Autonomic Changes on the Sinus Node Recovery Time in Patients with Sick Sinus Syndrome
- Abnormality of circulatory reflex and aldosterone response during head-up tilting in patients with primary aldosteronism.
- Sinus node function after selective elimination of sympathetic influences on the sinus node area of the dog.
- Influence of collateral flow reduction on electrophysiologic properties of preexisting ischemic area and inducibility of ventricular arrhythmias in the dog.
- The relationship between 24 hour total heart beats or ventricular arrhythmias and cardiopulmonary function in patients with Duchenne's muscular dystrophy.
- Elevation of plasma renin activity during pregnancy and rupture of a dissecting aortic aneurysm in a patient with primary aldosteronism.
- Effects of combined changes in serum calcium and potassium on QT interva. A study by holter electrocardiographic monitoring during hemodialysis.:A Study by Holter Electrocardiographic Monitoring during Hemodialysis
- The role of renal kallikrein and prostaglandin in the control of renin release.
- The mechanism of the control of renin release by beta-adrenergic receptors.
- Conduction Properties of the Antegrade Fast and Slow AV Nodal Pathways Associated with AV Nodal Reentrant Tachycardia.
- Effects of chronic hypokalemia on ventricular vulnerability during acute myocardial ischemia in the dog.
- Production of Active and Inactive Renin by Adrenal Explant Cultures and the Existence of a Prorenin Activating Enzyme in the Adrenal Gland.
- Contracted Form of Primary Endocardial Fibroelastosis in a Young Adult without Congestive Heart Failure
- Effect of angiotensin III on blood pressure, renin-angiotensin-aldosterone system in normal and hypertensive subjects.
- Long-term observation of cardiac function in Duchenne's muscular dystrophy. Evaluation using systolic time intervals and echocardiography.:Evaluation Using Systolic Time Intervals and Echocardiography
- Effects of Sympathetic and Parasympathetic Stimulation on the Induction of Atrial Flutter in Dogs with Aseptic Pericarditis.