The role of endogenous dopamine in congestive heart failure.
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概要
- 論文の詳細を見る
Although the effects of epinephrine and norepinephrine in congestive heart failure have been extensively studied, and exogenous dopamine, another of the catecholamines, has been widely used for the treatment of congestive heart failure, little attention has been paid to the physiological significance of endogenous dopamine in this condition. The present study was therefore designed to assess the physiological significance of endogenous dopamine in congestive heart failure.Nineteen patients with congestive heart failure caused by such conditions as acute myocardial infarction, valvular disease and dilated cardiomyopathy were examined before and after treatment with diuretics, digitalis and vasodilators. Electrolyte, creatinine and catecholamine concentrations in plasma and urine were analyzed.Urinary dopamine levels were increased in 13 out of 19 cases before treatment and returned to the normal range after treatment, falling from 2448±950.7 to 528.8±56.3μg/day (normal level, less than 700μg/day). Urinary dopamine excretion was markedly elevated within 24 hours after the onset of symptoms of heart failure, such as chest pain, palpitations and dyspnea. The relationship between urinary dopamine excretion and time after the onset of symptoms showed a strong statistical correlation (r=0.55, p<0.001). Urinary dopamine excretion was also well correlated with plasma dopamine concentration, urinary norepinephrine excretion and venous pressure.From these results, it is concluded that endogenous dopamine seems to play an important role during the acute phase of congestive heart failure.
- International Heart Journal刊行会の論文
著者
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TABEI Kaoru
Department of Nephrology, Jichi medical School
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Muto Shigeaki
Department Of Internal Medicine Division Of Nephrology Jichi Medical University
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Hosoda Saichi
Department Of Cardioangiology And Internal Medicine Jichi Medical School
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ASAKURA Shinji
Department of Cardiology and Kidney Center, Jichi Medical School
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ASANO Yasushi
Department of Cardiology and Kidney Center, Jichi Medical School
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TABEI Kaoru
Department of Cardiology and Kidney Center, Jichi Medical School
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MUTO Shigeaki
Department of Cardiology and Kidney Center, Jichi Medical School
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HOSODA Saichi
Department of Cardiology and Kidney Center, Jichi Medical School
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