Induction of Kinetic Cell Death and Its Underlying Mechanisms : 54th Annual Scientific Session of the Japanese Circulation Society
スポンサーリンク
概要
- 論文の詳細を見る
Using a modified Langendorff system. we established an experimental model of kinetic cell death in the rat heart. After calcium (5.5mM) was loaded for 20 min and 10^<-7> mol isoproterenol was then delivered to the perfusion medium. the hearts developed tonic contracture. Histological examination of the myocardium revealed widespread kinetic cell death. Stimulation of α -adrenoceptors with phenylephrine did not induce kinetic cell death. even after calcium loading. In our kinetic cell death model in the rat, the outflow of creatine phosphokinase into the perfusion medium was increased after isoproterenol application. with a peak occurring at 45 min. The peak transient increase in the intracellular calcium ion concentration (the Ca-transient) was measured using Fura2/AM, and was found to be augmented by increasing the calcium concentration of the perfusion medium. These results suggest that in the presence of an increased intracellular calcium concentration. even slight stimulation of β-adrenoceptors can easily induce myocardial injury.
- 社団法人日本循環器学会の論文
- 1991-11-20
著者
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Matsuda Ryuko
Department of Pneumology and Cardiology, Dokkyo Medical University School of Medicine
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Kaneko Noboru
Department of Pneumology and Cardiology, Dokkyo Medical University School of Medicine
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Hosoda Saichi
Department Of Cardiology The Heart Institute Of Japan Tokyo Women's Medical College
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Hosoda Saichi
Department Of Cardiology Sakakibara Heart Institute
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Horikawa Yoshifumi
Department of Cardiology, Sakakibara Heart Institute
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Uchida Tatsuro
The Cardiovascular Center of Sendai
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Uchida Tatsuro
Department Of Cardiology Tokyo Women' S Medical College
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Uchida Tatsuro
Department Of Cardiology Tokyo Women's Medical University
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Teraoka Kunihiko
Department of Cardiology, Tokyo Medical University Hospital
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Kaneko Noboru
Department Of Clinical Laboratory Medicine Dokkyo University School Of Medicine
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Kaneko Noboru
Department Of Cardiology And Pneumology Dokkyo Medical University
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Kaneko Noboru
Department Of Cardiology The Heart Institute Of Japan Tokyo Women's Medical College
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Teraoka Kunihiko
Department Of Cardiology Tokyo Women's Medical College
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Horikawa Yoshifumi
Department Of Cardiology And Pneumology Dokkyo University School Of Medicine
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Horikawa Yoshifumi
Department Of Cardiology Tokyo Women' S Medical College
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Horikawa Yoshifumi
Department Of Cardiology And Pneumology
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Matuda Ryuko
Department Of Pneumology And Cardiology Dokkyo Medical University School Of Medicine
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Matsuda Ryuko
Department Of Cardiology And Pneumology Dokkyo Medical University School Of Medicine
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Uchida Tatsuro
Department Of Cardiology Heart Institute Of Japan Tokyo Women's Medical College
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Matsuda Ryuko
Department Of Clinical Laboratory Medicine Dokkyo University School Of Medicine
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Hata Yoshihito
Department Of Pneumology And Cardiology Dokkyo Medical University School Of Medicine
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Matsuda Ryuko
Department Of Cardiology And Pneumology Dokkyo University School Of Medicine
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Teraoka Kunihiko
Department Of Cardiology Hachiouji Medical Center Tokyo Medical University
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Hosoda Saichi
Department Of Cardiology Heart Institute Of Japan Tokyo Women's Medical College
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Ueda Tetsurou
Department Of Cardiology Tokyo Women's Medical University
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Hosada Saichi
Department Of Cardiology Sakakibara Heart Institute
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Matsuda Ryuko
Department Of Biochemistry Tokyo Women's Medical College
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Kaneko Noboru
Heart Institute Of Japan Tokyo Women's Medical College
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Kaneko Noboru
The Heart Institute Of Japan Tokyo Women's Medical College
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Uchida Taturo
Department Of Internal Medicine Heart Institute Of Japan
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Hosoda Saichi
Department Of Cardiology And Internal Medicine
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Kaneko Noboru
Dept.of Cardiology Tokyo Women's Medical College
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Hosoda Saichi
Department Of Cardioangiology And Internal Medicine Jichi Medical School
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Teraoka Kunihiko
Department Of Cardiology Hachioji Medical Center Tokyo Medical University
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