Administration of Atrial Natriuretic Peptide Attenuates Reperfusion Phenomena and Preserves Left Ventricular Regional Wall Motion After Direct Coronary Angioplasty for Acute Myocardial Infarction
スポンサーリンク
概要
- 論文の詳細を見る
To evaluate the effects of synthetic human atrial natriuretic peptide (hANP) on myocardial reperfusion injury and left ventricular remodeling, 19 patients within 12h of a first attack of anterior myocardial infarction (AMI) underwent intracoronary injection of 25μg of hANP immediately after coronary angioplasty, combined with intravenous infusion of 0.025μg・kg^<-1>・min^<-1> of hANP initiated on admission for 1 week (hANP group) ; 18 similar patients had saline administered (control group). The incidences of premature ventricular contraction, ventricular tachycardia and/or fibrillation in the hANP group were significantly less than in the control group after coronary angioplasty. Left ventricular ejection fraction was significantly greater and left ventricular end-diastolic volume index was significantly smaller 6 months after coronary angioplasty. Left ventricular regional wall motion of the infarcted segments significantly increased. Thus, hANP remarkably suppressed reperfusion phenomena and preserved left ventricular function through improvement of regional wall motion of the infarcted segments after coronary angioplasty.
- 社団法人日本循環器学会の論文
- 2003-04-20
著者
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Kaneko Noboru
Department of Pneumology and Cardiology, Dokkyo Medical University School of Medicine
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Taguchi Isao
Department of Cardiology and Pneumology, Dokkyo University School of Medicine
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Kaneko Noboru
Department Of Cardiology And Pneumology Dokkyo University School Of Medicine
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Oida Akitugu
Department Of Cardiology And Pneumology Dokkyo University School Of Medicine
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Ohida Akitsugu
Department Of Cardiology And Pneumology Dokkyo University School Of Medicine
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Ogawa Kenichi
Department of Botany, Faculty of Science, Kyoto University
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Kuga Hideyo
Departments Of Cardiology And Pneumology Dokkyo University School Of Medicine
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Taguchi Isao
Department Of Cardiology And Pneumology Dokkyo Medical University School Of Medicine
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Taguchi I
Shimane Medical Univ. Izumo Jpn
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Kaneko Noboru
Department Of Cardiology And Pneumology Dokkyo Medical University School Of Medicine
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Kaneko Noboru
Department Of Cardiology And Pneumology Dokkyo Medical University
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Hoshi Toshiyasu
Department of Cardiology and Pneumology, Dokkyo University School of Medicine
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Sugimura Hiroyuki
Department of Cardiology and Pneumology, Dokkyo University School of Medicine
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Ogawa Kenichi
Departments Of Cardiology And Pneumology Dokkyo University School Of Medicine
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Taguchi Isao
獨協医科大学 医学部心臓血管肺内科
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Kaneko Noboru
Department Of Cardiology The Heart Institute Of Japan Tokyo Women's Medical College
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Abe Shichirou
Department of Cardiology and Pneumology, Dokkyo University School of Medicine
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Nakatsugawa Masatoshi
Department of Cardiology and Pneumology,Dokkyo University School of Medicine
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Sugimura Hiroyasu
Department of Cardiology and Pneumology,Dokkyo University School of Medicine
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Abe Shichirou
Department Of Cardiology And Pneumology Dokkyo Medical University School Of Medicine
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Hoshi Toshiyasu
Department Of Cardiology And Pneumology Dokkyo University School Of Medicine
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Sugimura Hiroyuki
Department Of Cardiology And Pneumology Dokkyo University School Of Medicine
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Nakatsugawa Masatoshi
Departments Of Cardiology And Pneumology Dokkyo University School Of Medicine
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Kaneko Noboru
The Heart Institute Of Japan Tokyo Women's Medical College
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Kuga Hideyo
Department of Cardiology and Pneumology, Dokkyo University School of Medicine
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