EFFECTS OF DILTIAZEM AND NITROGLYCERIN ON PROSTAGLANDIN F_<α>-INDUCED PERIODIC CONTRACTIONS OF ISOLATED HUMAN CORONARY ARTERIES
スポンサーリンク
概要
- 論文の詳細を見る
This study characterizes the inhibiting effect of diltiazem and nitroglycerin on periodic contractions of isolated human coronary arteries. Isometric force of coronary ring segments from sixty-nine cadavers was recorded in a muscle bath. To quantify the experimental results, we used 3×10^<-6> M prostaglandin F_<2α> to induce the periodic contractions of a certain force. When diltiazem was added during the periodic contractions, the amplitude of oscillations gradually decreased until eventually oscillations ceased completely. The process prior to the cessation of the oscillations was characterized mainly by the inhibition of the contraction phase. The inhibition rate at the time of the complete cessation of oscillations was 49.3±6.3% at 5×10^<-7>M. The time required for complete disappearance of oscillation s was dependent on the diltiazem concentration. When nitroglycerin was added during periodic contractions, the oscillations did not disappear. compared to the contraction phase, the relaxation phase was appreciably inhibited. With only 10^<-7> M diltiazem, the rate of inhibition of the contraction phase was 22.07.7%, where as the preliminary treatment with 510^<-8>M nitroglycerin led to a complete cessation of the oscillations, and suppression of the level of the contractions to a significantly greater extent, viz. 58.75.8% (p<0.001). Therefore, it is considered more effective in the treatment and prevention of coronary spasm to use diltiazem and nitroglycerin simultaneously rather than individually.
- 社団法人日本循環器学会の論文
- 1985-02-20
著者
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Nakanishi Norifumi
Division Of Cardiology Department Of Medicine National Cardiovascular Center
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Hosoda Saichi
Department Of Cardiology The Heart Institute Of Japan Tokyo Women's Medical College
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Nakanishi Norifumi
National Cardiovascular Center
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Nakanishi N
Department Of Cardiology Jichi Medical School
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Iino Tomoya
Department of Cardiology, Jichi Medical School
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Miyazawa Isao
Department of Cardiology and Internal Medicine, Jichi Medical School
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Kawasaki Ken-ichi
Department Of Cardiology Jichi Medical School
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Nakanishi Norifumi
Cardiac Division Department Of Internal Medicine National Cardiovascular Center
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SEKI KATUMI
Department of cardiology, Jichi Medical School
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MATUMOTO NAOHIRO
Department of cardiology, Jichi Medical School
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NAKANISI NORIFUMI
Department of cardiology, Jichi Medical School
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SEKI KATSUMI
Department of Cardiology, Jichi Medical School
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MATSUMOTO NAOHIRO
Department of Cardiology, Jichi Medical School
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Saito K
The Second Department Of Internal Medicine Tohoku University School Of Medicine
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Seki Katsumi
Department Of Cardiology Jichi Medical School
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Iino Tomoya
Department Of Cardiology Jichi Medical School
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Seki Katsumi
Department Of Pathology Jichi Medical School
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Hosoda Saichi
Department Of Cardiology Heart Institute Of Japan Tokyo Women's Medical College
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Kawasaki Ken-ichi
Department Of Cardiology And Internal Medicine
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Matsumoto Naohiro
Department Of Cardiology Jichi Medical School
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Hosoda Saichi
Department Of Cardiology And Internal Medicine
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Hosoda Saichi
Department Of Cardioangiology And Internal Medicine Jichi Medical School
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Miyazawa Isao
Department of Cardiology, Jichi Medical School
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