Left ventricular mass and blood pressure during ergometric exercise in primary hypertension.

スポンサーリンク

概要

• 論文の詳細を見る

• The pathophysiology of left ventricular hypertrophy (LVH) in hypertensive patients is still an intriguing point. The lack of a close relationship between LVH and systolic or diastolic blood pressure at rest, previously observed by other investigators, was confirmed in our group of 45 patients with uncomplicated primary hypertension. The strength of correlation between echocardiographic left ventricular mass (LV Me) and blood pressure, expressed as incremental area (IA=total area under the curve-basal area), however, increased during bicycle exercise testing (r=0.33, p<0.05 for diastolic blood pressure; r=0.39, p<0.01 for systolic blood pressure; r=0.41, p<0.01 for mean arterial pressure). Other echocardiographic parameters of myocardial mass such as LVM index (LVMI) and septal thickness (ST) were also significantly correlated with blood pressure during exercise.These results suggest either that blood pressure during exercise is a better index of the cardiac workload than resting blood pressure or that the pathogenesis of cardiac hypertrophy involves an enhanced reactivity to adrenergic drive, particularly stimulated during ergometric exercise.Increased blood pressure alone, however, only partly accounts (about 20%) for the increase in myocardial mass in hypertensive patients; other factors, therefore, need to be further investigated for a better understanding of the pathophysiology of left ventricular hypertrophy.

• International Heart Journal刊行会の論文

著者

• MANCINI Mario

  Institute of Internal Medicine and Metabolic Diseases, Clinica Medica, 2nd Medical School, University of Naples

• MANCINI Mario

  Institute of Internal Medicine and Metabolic Diseases, 2nd Medical School, University of Naples

• SIMONE Giovanni

  Institute of Internal Medicine and Metabolic Diseases, Second Medical School, University of Naples

• FASANO M.

  Institute of Internal Medicine and Metabolic Diseases, Clinica Medica, 2nd Medical School, University of Naples

• FERRARA L.

  Institute of Internal Medicine and Metabolic Diseases, Clinica Medica, 2nd Medical School, University of Naples

• MANCINI Marcello

  Institute of Internal Medicine and Metabolic Diseases, Clinica Medica, 2nd Medical School, University of Naples

• SIMONE Giovanni

  Institute of Internal Medicine and Metabolic Diseases, Clinica Medica, 2nd Medical School, University of Naples

• SIMONE Giovanni

  Institute of Internal Medicine and Metabolic Diseases, 2nd Medical School, University of Naples

関連論文

• Cardiovascular Response to Mental Stress and to Handgrip in Children : The Role of Physical Activity
• Once a day indapamide therapy in hypertension. Effects on the heart and peripheral arterial circulation.:Effects on the Heart and Peripheral Arterial Circulation
• Slow-release nifedipine versus placebo in the treatment of arterial hypertension. A double blind ergometric evaluation of cardiac workload.
• Left ventricular mass and blood pressure during ergometric exercise in primary hypertension.
• Noninvasive assessment of hemodynamic changes during therapy with nitrendipine in arterial hypertension.
• Ketanserin and Hydrochlorothiazide in the Treatment of Arterial Hypertension.

スポンサーリンク