Once a day indapamide therapy in hypertension. Effects on the heart and peripheral arterial circulation.:Effects on the Heart and Peripheral Arterial Circulation

スポンサーリンク

概要

• 論文の詳細を見る

• Indapamide, a sulphonamide derivative, was prescribed for 8 weeks at low dose (2.5mg once a day) to 14 hypertensive patients in order to investigate its effects on systolic and diastolic blood pressure (SBP, DBP), cardiac function and peripheral arterial resistance (PAR). During treatment we observed decreases in both SBP and DBP without any change in HR in the supine and standing positions and on exercise. As a result cardiac work was significantly reduced. Slight changes in pre-ejection period (PEP) and left ventricular ejection time (LVET) along with a more significant decrease in rate of rise of left ventricular pressure (DBP to PEP ratio) were observed during treatment. An increase in RBF and a decrease in PAR were also detected in the peripheral circulation.These findings may indicate that indapamide antagonizes the cardiovascular effects of catecholamines.

• International Heart Journal刊行会の論文

著者

• GIUMETTI Dante

  Institute of Internal Medicine and Metabolic Diseases, Second Medical School, University of Napoli

• FERRARA Liberato

  Institute of Internal Medicine and Metabolic Diseases, Second Medical School, University of Napoli

• FASANO Maria

  Institute of Internal Medicine and Metabolic Diseases, Second Medical School, University of Napoli

• SORO Stefano

  Institute of Internal Medicine and Metabolic Diseases, Second Medical School, University of Napoli

• IANNUZZI Arcangelo

  Institute of Internal Medicine and Metabolic Diseases, Second Medical School, University of Napoli

• STRAZZULLO Pasquale

  Institute of Internal Medicine and Metabolic Diseases, Second Medical School, University of Napoli

• MANCINI Mario

  Institute of Internal Medicine and Metabolic Diseases, Second Medical School, University of Napoli

• SORO Stefano

  Institute of Internal Medicine and Metabolic Diseases, 2nd Medical School, University of Naples

• FASANO Maria

  Institute of Internal Medicine and Metabolic Diseases, 2nd Medical School, University of Naples

• MANCINI Mario

  Institute of Internal Medicine and Metabolic Diseases, 2nd Medical School, University of Naples

• FERRARA Liberato

  Institute of Internal Medicine and Metabolic Diseases, 2nd Medical School, University of Naples

関連論文

• Cardiovascular Response to Mental Stress and to Handgrip in Children : The Role of Physical Activity
• Once a day indapamide therapy in hypertension. Effects on the heart and peripheral arterial circulation.:Effects on the Heart and Peripheral Arterial Circulation
• Slow-release nifedipine versus placebo in the treatment of arterial hypertension. A double blind ergometric evaluation of cardiac workload.
• Cardiovascular Response to Adrenergic Stimulation during Treatment with Tertatolol. A New Non-Cardioselective Beta-Blocking Agent in Primary Hypertensive Patients.:A New Non-Cardioselective Beta-Blocking Agent in Primary Hypertensive Patients
• Left ventricular mass and blood pressure during ergometric exercise in primary hypertension.
• Noninvasive assessment of hemodynamic changes during therapy with nitrendipine in arterial hypertension.

スポンサーリンク