Noninvasive assessment of hemodynamic changes during therapy with nitrendipine in arterial hypertension.

スポンサーリンク

概要

• 論文の詳細を見る

• Changes in hemodynamic variables regulating systolic function were examined by M-mode echocardiography in 14 patients with long-duration primary uncomplicated hypertension treated with nitrendipine once daily (20mg). At the end of treatment (8th week) blood pressure and peripheral resistance were greatly reduced (p<0.0001), while the indices of cardiac function (ejection fraction and cardiac index) showed significant increases (p<0.01). The variations in ejection fraction were analyzed by multiple linear regression and were mainly influenced by the decrease in end-systolic stress (contribution: 60%). At baseline, despite no radiographic or clinical signs of heart failure, 6 of the studied patients showed impaired systolic function, likely due to the strength of other variables (age, risk factors); in those patients, systolic function was clearly enhanced at the end of treatment, while no change was found in patients with initial normal pump function. Changes in cardiac output were due toasignificant increase in heart rate in patients with normal pump function and to improved stroke volume in the others. Left ventricular mass index was slightly reduced (p<0.005), primarily because of the reduction in end-diastolic volume (p<0.01). When analyzed by the 2 subgroups (with or without impaired systolic function), the left ventricular mass index appeared to be significantly reduced only in those patients with normal basal pump function. This difference was most likely due to the different effects of treatment on enddiastolic volume.

• International Heart Journal刊行会の論文

著者

• SORO Stefano

  Institute of Internal Medicine and Metabolic Diseases, 2nd Medical School, University of Naples

• FASANO Maria

  Institute of Internal Medicine and Metabolic Diseases, 2nd Medical School, University of Naples

• MANCINI Mario

  Institute of Internal Medicine and Metabolic Diseases, 2nd Medical School, University of Naples

• FERRARA Liberato

  Institute of Internal Medicine and Metabolic Diseases, 2nd Medical School, University of Naples

• LORENZO Luigi

  Institute of Internal Medicine and Metabolic Diseases, 2nd Medical School, University of Naples

• SIMONE Giovanni

  Institute of Internal Medicine and Metabolic Diseases, 2nd Medical School, University of Naples

• COSTANTINO Guido

  Institute of Internal Medicine and Metabolic Diseases, 2nd Medical School, University of Naples

関連論文

• Cardiovascular Response to Mental Stress and to Handgrip in Children : The Role of Physical Activity
• Once a day indapamide therapy in hypertension. Effects on the heart and peripheral arterial circulation.:Effects on the Heart and Peripheral Arterial Circulation
• Slow-release nifedipine versus placebo in the treatment of arterial hypertension. A double blind ergometric evaluation of cardiac workload.
• Cardiovascular Response to Adrenergic Stimulation during Treatment with Tertatolol. A New Non-Cardioselective Beta-Blocking Agent in Primary Hypertensive Patients.:A New Non-Cardioselective Beta-Blocking Agent in Primary Hypertensive Patients
• Left ventricular mass and blood pressure during ergometric exercise in primary hypertension.
• Noninvasive assessment of hemodynamic changes during therapy with nitrendipine in arterial hypertension.

スポンサーリンク