Role of Autonomic and Non-Autonomic Circulatory Components in Borderline Hypertension in Young Men
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概要
- 論文の詳細を見る
The role of autonomic nervous system and non-autonomic components in hemodynamic abnormalities of young patients with borderline hypertension was examined by comparing the effects of sequential pharmacological autonomic blockade on hemodynamics between 8 patients with borderline hypertension (mean age 20.0±0.2) and 10 normotensive subjects (mean age 19.3±0.2). Propranolol (0.2mg/Kg), atropine (0.04mg/Kg), and phentolamine (10 or 15mg) were given intravenously in that order to produce "total" autonomic blockade. Increased cardiac index, heart rate, and mean arterial blood pressure with normal peripheral vascular resistance were noted at rest in patients with borderline hypertension. Cardiac index and heart rate in patients with borderline hypertension were normalized by propranolol, but after "total" autonomic blockade mean arterial blood pressure and peripheral vascular resistance were higher in patients with borderline hypertension as compared to those in normotensive subjects. These results suggest that, although autonomic nervous system control of circulation is abnormal, non-autonomic components play an important role in maintaining increased peripheral vascular resistance in borderline hypertension in young men.
- International Heart Journal刊行会の論文
著者
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Tomoike Hitonobu
Research Institute Of Angiocardiology And Cardiovascular Clinic Faculty Of Medicine Kyushu Universit
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Takeshita Akira
Research Institute Of Angiocardiology And Cardiovascular Clinic Faculty Of Medicine Kyushu Universit
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Nakamura Motoomi
Research Institute of Angiocardiology and Cardiovascular Clinic, Faculty of Medicine, Kyushu Univers
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Tomoike Hitonobu
Reseach Institute Of Angiocardiology And Cardiovascular Clinic Faculty Of Medicine
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Nakamura Motoomi
Reseach Institute Of Angiocardiology And Cardiovascular Clinic Faculty Of Medicine
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Tanaka Senichi
Research Institute Of Angiocardiology And Cardiovascular Clinic Kyushu University Medical School
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Tanaka Senichi
Res. Inst. Of Angiocardiol Kyushu Univ. Med. School:cardiov. Clinic Kyushu Univ. Med. School
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Takeshita Akira
Research Institute Of A Ngiocardiology And Cardiovascular Clinic Faculty Of Medicine Kyushu Universi
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TAKESHITA Akira
Research Institute of Angiocardiology and Cardiovascular Clinic, Kyushu University Medical School
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TOMOIKE Hitonobu
Research Institute of Angiocardiology and Cardiovascular Clinic, Kyushu University Medical School
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