An Observation of Thromboxane A2 in Arterial Blood after Cholesterol Feeding in Rabbits
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概要
- 論文の詳細を見る
Agents responsible for the entry of cholesterol-bearing lipoproteins into the arterial wall represent local risk factors in atherogenesis. In an attempt to identify these agents, we inserted a catheter into the ascending aorta of rabbits and 5ml of arterial blood sample was withdrawn. The contraction of the aortic strip of rabbit against Piper and Vanes antagonists with application of this sample was observed. Samples ob-tained after feeding of 1Gm/Kg of cholesterol and after an intravenous administration of thromboxan A2 (TXA2) contracted the aortic strip. Samples from non-treated rabbits or those obtained after intravenous administration of 10μg of epinephrine or norepinephrine did not contract the strip. Previous administration of 20mg/Kg of indomethacin decreased the contraction developed after feeding of 1Gm/Kg of cholesterol. It was suggested that TXA2 might be released into the arterial blood by the ingestion of cholesterol and might be one of the agents responsible for the entry of lipoproteins.
- International Heart Journal刊行会の論文
著者
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SHIMAMOTO Takio
Dept. of Intern. Med. Tokyo Ika-Shika National Univ.
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KOBAYASHI MASAHIKO
Japan Atherosclerosis Research Institute
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SHIMAMOTO TAKIO
Japan Atherosclerosis Research Institute
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Shimamoto Takio
Japan Atherosclerosis Research Foundation
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Shimamoto Takio
Department Of Internal Medicine Tokyo Medical And Dental University
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TAKAHASHI Takeo
Japan Atherosclerosis Research Institute, Faculty of Medicine, University of Tokyo
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TAKASHIMA Yoshimi
Japan Atherosclerosis Research Institute, Faculty of Medicine, University of Tokyo
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SAKAMOTO Mitsugu
Japan Atherosclerosis Research Institute, Faculty of Medicine, University of Tokyo
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MOROOKA Shigenori
Second Department of Internal Medicine, Faculty of Medicine, University of Tokyo
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SHIMAMOTO Takio
Japan Atherosclerosis Research Institute, Faculty of Medicine, University of Tokyo
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SHIMAMOTO Takio
Japan Atherosclerosis Institute
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TAKASHIMA Yoshimi
Japan Atherosclerosis Research Institute
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