Oxatomide(KW-4354)の薬理作用-4-ラット腹腔浸出細胞および肺切片からのHistamine遊離におよぼす影響

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The present study was carried out to evaluate the inhibitory effect of oxatomide and disodium cromoglycate (DSCG) on the histamine release from rat PEC and lung slices induced by antigen-antibody reaction, concanavalin A, compound 48/80 and A-23187. Oxatomide in the range of 1 μM to 10 μM inhibited the allergic histamine release from rat PEC and lung slices induced by antigen-antibody reaction in the presence of phosphatidyl-L-serine (PS). Although the inhibitory action of oxatomide was significant even at a concentration of 1 μM, the action did not increase with an increase in concentration of the drug. DSCG showed a concentration-dependent inhibition on the allergic histamine release from rat PEC and lung slices in the range of 10 μM to 100 μM. The histamine release from rat PEC induced by the combined treatment of concanavalin A and PS was inhibited by oxatomide (0.1 to 10 μM) and DSCG (10 to 100 μM). Oxatomide (up to 10 μM) showed no effect on the histamine release induced by compound 48/80, while DSCG in the range of 10 μM to 100 μM showed a concentration dependent inhibition of the release. Oxatomide at a concentration of 10 μM showed a significant inhibition on the histamine release induced by the calcium ionophore A-23187. On the other hand, DSCG had no effect on this reaction. Oxatomide at high concentrations did not stimulate the histamine release by itself.
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