脊髄の電気活動(自発々射,誘発電位)に対するCardiazolの作用 Cardiazolは抗Pentobarbital剤たりうるか

概要

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It has been observed that cardiazol acts facilitatorily, and that the facilitation is provided by suppression of inhibitory mechanisms. The effects of this compound on the spinal cord reflexes have been investigated by this author. The results are as follows: Cardiazol depressed the dorsal activities in all preparations. Regarding ventral activities, the compound accelerated the S. B. S. reflex response, but did not vary either the M. S. R. or the P. S. R. to any great extent in the unanesthetized, immobilized preparation. S. B. S. reflex response was never observed in the spinal preparation. Cardiazol acts not only on the spinal cord itself, but also on the supraspinal mechanisms. The main site of action, however, appeared to be at the supraspinal level, and the mode of action is presumably the suppression of presynaptic inhibition. S. B. S. reflex can be induced according to the depression of presynaptic inhibition and by means of a decrease in the postsynaptic inhibition. Cardiazol may be classified as superior to diazepam-like antagonist drugs, rather than to pentobarbital-like compounds.
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