長経路脊髄後根反射におよぼすDiazepam，Oxazepamの影響

概要

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The interlimb dorsal root reflex has not been described yet in the literature. As diazepam increased the segmental dorsal root reflex, it was utilized for discussion whether the interlimb dorsal root reflex exists. Both long dorsal and ventral root reflexes of the spinal cord were most strikingly observed on the im-mobilized un-anesthetized preparation. When the long dorsal root reflex was clearly observed, diazepam increased it further, and even when it was difficult to be observed, the compound strengthened it. On the contrary, the long ventral root reflex was depressed. Oxazepam showed the same action as diazepam. Therefore, the interlimb reflexes are present on the dorsal site (afferent) as well as on the ventral site (efferent). Its appearance, however, in part, seems to depend on the activities of the supraspinal mechanisms. It is thought that the mentioned reflex plays some un-negrigible roles concerning the motor and sensory activities, and contributes greately to their modification with the drugs. Oxazepam is a new diazepamlike drug.
社団法人日本薬理学会の論文