担子菌類の抗腫瘍作用について

概要

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This report describes the tumor-inhibiting effect against Sarcoma 180 in mice of some wild and cultured Basidiomycetes. Results: 1. Some of wild and cultured Basidiomycetes preparations given intraperitoneally had an antitumor effect. Complete regression of the tumor was observed in many cases. 2. Both per- and post-treatment with PMS were effective, and a single injection of 100mg/kg with PMS was most effective. 3. Poly I: Poly C shows the tumor-inhibiting effect, however the effect was seen during the early stage of the tumor growth. 4. PMS was ineffective against Ehrlich ascites tumor in mice. 5. Acid mucopolysaccharides as Chondroitin sulfate was decreased an antitumor effect of PMS. 6. The intraperitoneal administration with PMS was most effective against spontane-ous mammary tumor in C3H/He mice.
社団法人日本薬理学会の論文