四塩化炭素によるThiopental麻酔の強化に関する研究

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概要

• 論文の詳細を見る

• Thiopental sleeping time and anesthetic dose of thiopental were examined in rats at 24 hours after administration of CCl4. It was found that CCl4 increased the sleeping time and reduced the anesthetic dose. Tissue distribution studies revealed that potentiation by CCl4 of thiopental anesthesia was attributed to an increased penetration of the barbiturate into the brain. Biochemical studies showed that plasma of CCl4-treated rats had relatively low quantities of albumin and did not have enough capacity for thiopental binding. Altered distribution of thiopental might be due to a hypoalbuminemia induced by CCl4. No changes in the sensitivity of central nervous system and in the permeability of blood-brain barrier were observed.

• 社団法人 日本薬理学会の論文

著者

• 布施 昌孝

  札幌医科大学薬理学教室

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• 四塩化炭素によるThiopental麻酔の強化に関する研究

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