<SUP>3</SUP>H- 標識強心配糖体の猫およびモルモット心筋における細胞内分布

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概要

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• Isolated cat and guinea-pig hearts were perfused with 10<SUP>-7</SUP>M <SUP>3</SUP>H-ouabain or <SUP>3</SUP>H-digitoxin for 30 min. The subcellular distribution of cardiac glycosides was investigated. (1) In cat hearts, the digitoxin uptake was approximately 6 times greater than the ouabain uptake. Upon fractionation, the concentration of glycosides in the microsomal fraction was the highest, being 8 ?? 17-fold range of that seen in the other fractions. (2) In guinea-pig hearts, the subcellular distribution of glycosides showed the same pattern as in cat hearts. (3) From these findings, it was suggested that cardiac glycosides might have a greater affinity to microsomal fraction regardless of animal species.

• 社団法人 日本薬理学会の論文

著者

• 川岸 俊作

  札幌医科大学大学院

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• 猫心筋のSarcoplasmic reticulumおよび細胞膜の強心配糖体結合
• 3H- 標識強心配糖体の猫およびモルモット心筋における細胞内分布

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