猫心筋のSarcoplasmic reticulumおよび細胞膜の強心配糖体結合

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概要

• 論文の詳細を見る

• The binding capacity of ouabain or digitoxin by sarcoplasmic reticulum (SRF) isolated from cat heart muscle was found to be about 7-9 times as much as that by cell membrane from cat heart muscle. Acetone treatment of SRF caused a marked decrease in the binding capacity of ouabain and digitoxin. SRF pretreated with phospholipase C was decreased in content of phospholipid, in the ATPase activity, in the Ca-binding capacity and in the binding capacity of ouabain or digitoxin, while SRF pretreated with digitonin was decreased in content of cholesterol, but not in phospholipid content, in ATPase activity, in the Ca-binding capacity and in the binding capacity of ouabain or digitoxin. From these findings, it might be concluded that SRF was the major binding site for cardiac glycosides and that the content of phospholipid of SRF plays an important role in the drug-binding capacity.

• 社団法人 日本薬理学会の論文

著者

• 川岸 俊作

  札幌医科大学大学院

• 川岸 俊作

  札幌医科大学薬理学教室

関連論文

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• 猫心筋のSarcoplasmic reticulumおよび細胞膜の強心配糖体結合
• 3H- 標識強心配糖体の猫およびモルモット心筋における細胞内分布

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