新向精神薬“Oxazolam”の作用に関する神経薬理学的研究

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The effects of oxazolam (OZP) upon the central nervous system and peripheral isolated membrane were studied, and following action were observed.<BR> 1) The hyperirritable emotional behavior of rats after destruction of their septal area was depressed. 2) In the mouse pretreated with MAO inhibitor, both reserpine-induced locomotive hyper-activity and dl-5-HTP-evoked tremor were inhibited, but hyperexcitable state after DOPA administration was not. 3) In the rabbit, duration of reactive after discharge in amygdala and propagated one in hippocampus evoked by stimulation of the former nucleus at high frequency were slightly shortened, and waves with slow frequency became observable in spontaneous EEG of amygdala and hippocampus.<BR> 4) In decerebrate cat, the fusimotoneuronal discharges were slightly depressed. 5) Following responses in cat were not changed after OZP; (i) spontaneous EEG and arousal reaction by the stimulation of mesencephalic reticular formation, post. hypothalamus and sciatic nerve in acute immobilized, encephale isole and chronic intact cat. (ii) augmenting and recruiting responses. (iii) spinal reflexes. 6) The contraction of nictiating membrane by the stimulation of post. hypothalamus was inhibited, however, that obtained by postganglionic nerve stimulation and by noradrenarine injection were not altered. 7) The conduction of impulses in isolated fibers of either frog or lobster and transmission of neuromusclar junction and membrane pötential of sartorius muscle of frog were not changed. 8) In the rabbit the muscle contraction by single shock stimulation of the sciatic nerve was not affected, but the blocking action of d-tubocurarine was potentiated.
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新向精神薬“Oxazolam”の作用に関する神経薬理学的研究

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