リンパ球幼若化の機構

概要

論文の詳細を見る
The process of lymphocyte activation in vitro can be divided into four distinct steps three of which are mitogen-dependent and the fourth is mitogen-independent. The first step is attachment of the mitogens to the cell membrane. The second step is activation of resting lymphocytes by reaction with activating receptor system. During these two phases the cells become preactivated. The third step is determination of lymphocyte response. In the fourth step the cells proceed to the S phase and eventually they may clivide, regardless of the presence or absence of mitogen.<BR>In this review I describe about important things which are required during the mitogen-dependent steps (Carbohydrate hinding specificities of mitogenic lectins, natures of receptor sites of lymphocyte cell surface for mitogenic lectins, changes of plasma membrane after binding of mitogenic lectins to lymphocyte cell surface, and kinetics of lymphocyte stimulation by mitogenic lectins).
日本生物物理学会の論文