Spontaneous Basal Cell Carcinoma of the Submandibular Gland in a Rat
スポンサーリンク
概要
- 論文の詳細を見る
At necropsy, a white nodule (about 5 × 3 mm in size) was observed in the right submandibular gland of a 10-week-old female GALAS rat. Histopathologically, oval to spindle-shaped and pale basophilic tumor cells proliferated closely, and formed variably sized foci. The nodule partially spread into or invaded the surrounding normal tissue, and necrotic foci were recognized in the tumor. Immunohistochemically, the nuclei of the tumor cells showed a diffusely positive reaction for p63, and the cytoplasm showed a diffusely positive reaction for cytokeratin and negative reaction for αSMA, vimentin, desmin and S-100. Many tumor cells were positive for PCNA. Ultrastructurally, the tumor cells contained many tonofilaments in the cytoplasm and a few desmosomes at the intercellular portion. Based on these findings, the tumor was diagnosed as a basal cell carcinoma originating from the duct in the rat submandibular gland.
著者
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Kobayashi Yoshihiko
Sugi Institute of Biological Science Co., Ltd.
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Kobayashi Yoshihiko
Kobuchisawa Research Laboratories Fuji Biomedix Co. Ltd.
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Akie Yasuki
Sugi Institute of Biological Science, Japan
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Eda Hiro
Sugi Institute of Biological Science Co., Ltd.
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Kajino Emiko
Sugi Institute of Biological Science Co., Ltd.
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Tate Yoshiki
Sugi Institute of Biological Science Co., Ltd.
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Hiruma Masami
Sugi Institute of Biological Science Co., Ltd.
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Saito Akemi
Sugi Institute of Biological Science Co., Ltd.
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Kadota Toshihito
Sugi Institute of Biological Science Co., Ltd.
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Akie Yasuki
Sugi Institute Of Biological Science
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Kobayashi Yoshihiko
Sugi Institute Of Biological Science Co. Ltd.
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Eda Hiro
Sugi Institute Of Biological Science Co. Ltd.
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Kajino Emiko
Sugi Institute Of Biological Science Co. Ltd.
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Tate Yoshiki
Sugi Institute Of Biological Science Co. Ltd.
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