Smooth Muscle Hamartoma of the Nipple in a Beagle Dog

概要

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A smooth muscle hamartoma of the nipple was found in a 9-month-old beagle dog. No abnormalities were observed on necropsy. Histopathologically, there was a solitary lesion measuring 3 × 1 mm in size in the dermis of the nipple. The lesion was unencapsulated but well demarcated and was composed of numerous intersecting fascicles, with the nuclei of the some of the cells being round or oval-shaped, and those of others being fusiform with blunt edges. These fascicles, associated with the nipple smooth muscle, were surrounded by a large amount of mature collagen. There was no evidence of cytologic atypia or mitotic figures. Immunohistochemistry showed positive staining for alpha-smooth muscle actin (αSMA), but negative staining for S-100 protein, cytokeratin and p63, suggesting that the lesion was derived from the smooth muscle of the nipple. Therefore, a diagnosis of smooth muscle hamartoma of the nipple was made.
日本毒性病理学会の論文
2007-09-30