Ex vivo Tissue Discrimination by Visible and Near-Infrared Spectra with Chemometrics

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概要

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• The risk of infections from zoonotic pathogens of tissues and/or tissue-derived products has been increasing. One preventive approach in reducing infection risk is tissue decontamination, where selection and screening of highly infectious tissues are strictly followed. Therefore, the development of reliable analytical methods for rapid tissue discrimination is essentially important. In the present study, a procedure has been developed for intact tissue discrimination on the basis of multivariate analysis of visible and near-infrared (Vis-NIR) spectra of certain tissues such as brain, liver, kidney and testis of mice without any pretreatment. Transmittance spectra in the 600- to 1000-nm regions were subjected to a principal component analysis (PCA), and leave-out cross-validation was employed to develop multivariate models for tissue discrimination. The plot of PCA scores against Vis-NIR spectra of brains, kidneys, livers and testes from 11 mice portrayed reliable tissue discrimination. This result suggests that Vis-NIR spectroscopy combined with chemometrics analysis may provide a potentially useful approach for rapid non-destructive discrimination of tissues.

• 公益社団法人 日本獣医学会の論文

著者

• Sakudo Akikazu

  Department Of Molecular Immunology School Of Agricultural And Life Sciences University Of Tokyo

• TSENKOVA Roumiana

  Faculty of Agriculture, Kobe University

• TEI Kyoko

  Faculty of Agriculture, Kobe University

• Tei Kyoko

  Faculty Of Agriculture Kobe University

• Onodera Takashi

  Department Of Molecular Immunology Faculty Of Agriculture The University Of Tokyo

• Tsenkova Roumiana

  Faculty Of Agriculture Kobe University

• Ikuta Kazuyoshi

  Department Of Biophysical Chemistry Faculity Of Pharmaceutical Sciences Hokkaido University

• MORITA Hiroyuki

  Faculty of Agriculture, Kobe University

• SAKUDO Akikazu

  Department of Molecular Immunology, School of Agricultural and Life Sciences, The University of Tokyo

• ONODERA Takashi

  Department of Molecular Immunology, School of Agricultural and Life Sciences, The University of Tokyo

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