Real-time Tissue Elastographyを用いた肝線維化の非侵襲的評価法〜Liver Fibrosis Index（LF Index）によるstage判定

概要

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To evaluate the effectiveness of Real-time Tissue Elastography (RTE) in staging of liver fibrosis non-invasively, we performed RTE on 310 patients with chronic hepatitis C (and/or liver cirrhosis) and 15 healthy volunteers. Nine image features were extracted from each RTE image and a multiple regression analysis was then performed to derive the regression equation. This equation calculates Liver Fibrosis Index (LF Index), which in turn predicts F stage of the liver. LF Index not only correlates highly with the F stage (r=0.68) of the liver fibrosis, but also it shows significant differences in LF Index values (p<0.001) between each stage of the fibrosis. Thus, we can conclude that RTE is a promising method to evaluate the liver fibrosis noninvasively.