Preparation of osteocompatible Si(IV)-enriched chitosan–silicate hybrids
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概要
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Chitosan–γ-glycidoxypropyltrimethoxysilane (GPTMS)–tetraethoxysilane (TEOS) hybrid membranes were prepared by the sol–gel method. The effects of Si(IV) released from them on cell proliferation and differentiation were examined in terms of cell metabolic activity and the alkaline phosphatase (ALP) activity of MG63 osteoblastic cells. The amount of Si(IV) released from the hybrid membranes increased with the TEOS content. The released Si(IV) inhibited cell proliferation but promoted cell differentiation. Thus, the osteocompatibility of the chitosan hybrid membranes in the chitosan–GPTMS–TEOS system can be controlled by the amount of Si(IV) released from them when they are applied to cell culture.
著者
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SHIROSAKI Yuki
Graduate School of Natural Science and Technology, Okayama University
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HAYAKAWA Satoshi
Graduate School of Natural Science and Technology, Okayama University
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OSAKA Akiyoshi
Graduate School of Natural Science and Technology, Okayama University
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Shirosaki Yuki
Graduate School Of Natural Sci. And Technol. Okayama Univ.
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TSURU Kanji
Faculty of Engineering, Okayama University
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Tsuru Kanji
Department Of Biomaterials Faculty Of Dental Science Kyushu University
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Hayakawa Satoshi
Graduate School Of Natural Sci. And Technol. Okayama Univ.
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MORIBAYASHI Hirofumi
Graduate School of Natural Science and Technology, Okayama University
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NAKAMURA Yuri
Faculty of Engineering, Okayama University
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GIBSON Iain
Institute of Medical Sciences, University of Aberdeen
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TSURU Kanji
Faculty of Dental Science, Kyushu University
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