A Case of Membranous Nephropathy with Primary Biliary Cirrhosis and Cyclosporine-induced Remission

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概要

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• We report a case of membranous nephropathy with primary biliary cirrhosis (PBC). A 76-year-old Japanese man had been treated for PBC and was referred to our department because of acute severe proteinuria (10 g/day). Renal biopsy was performed and was compatible with a diagnosis of membranous nephropathy. The patient was treated with cyclosporine A (CsA; Neoral®), which was followed by normalization of liver function and partial remission of proteinuria (0.68 g/day) within six months without any significant side effects. This case suggests that CsA monotherapy is effective for the treatment of both liver dysfunction and membranous nephropathy associated with PBC.

著者

• Itoh Hiroshi

  Division 1 Department Of Pathology Kobe University School Of Medicine

• Wakino Shu

  Division Of Endocrinology Metabolism And Nephrology School Of Medicine Keio University

• Hayashi Koichi

  Division Of Endocrinology Metabolism And Nephrology School Of Medicine Keio University

• Hashiguchi Akinori

  Department Of Pathology Keio University School Of Medicine

• Konishi Kounosuke

  Division of Endocrinology, Metabolism and Nephrology, Department of Internal Medicine, Keio University, Japan

• Sakamaki Yusuke

  Division of Endocrinology, Metabolism and Nephrology, Department of Internal Medicine, Keio University, Japan

• Hayashi Matsuhiko

  Center for Apheresis and Dialysis, Keio University, Japan

• Fukuda Seiichi

  Division of Endocrinology, Metabolism and Nephrology, Department of Internal Medicine, Keio University, Japan

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