生体関連金属錯体の電気化学とその応用

概要

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In this account, typical achievements for these 30 years related to metalloprotein electrochemistry using various functional electrodes and related fields are reviewed, for which JSCC award of 2009 was honorary presented to the author. The main achievements are: 1) the developments of functional electrodes for the direct rapid electron-transfer of metalloproteins, such as cytochrome c, myoglobin and ferredoxin, and their applications to analyze the biological functions of the metalloproteins using usual electrochemical techniques. Some surface structures of the electrodes at the molecular level have been studied to understand the surface functions of the electrode for the rapid electron transfer of metalloproteins on the electrode surfaces. 2) Biological functions of key amino-acids of myoglobin and ferredoxin have also been studied by comparing electrochemical behavior with those of mutated molecules. 3) Electrochemistry of metal-complexes, as models of metalloproteins, and its application to develop electrochemical-sensing devices, are also given. In addition, 4) recent developments on direct electron-transfer of enzymes, and new sugar (such as glucose and fructose) -air bio-fuel batteries at the level of practical use, >10 mA/cm⊃2; in current and > a few mW/cm⊃2; in power, are introduced.