マウス行動表現型解析プラットフォームの国際的標準化の背景と現状

概要

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The mouse is a good animal model that helps us to elucidate various human and other mammalian genetic systems. Several international programs are under way to introduce mutations into every gene in the mouse genome. However, the phenotypes exhibited by every mutant mouse generated in these programs should be determined to reach the goal of these programs. Large-scale phenotyping for genome-wide functional annotation needs efforts by scientists in the infrastructural, logistical, and informatics area. These include the use of standardized procedures for phenotyping and integrated databases with comparable datasets. In this paper, we shall discuss the trends in recent mouse-mutagenesis projects, descriptions of a large amount of phenotyping data from mutants, and descriptions of experimental procedures in an international unified database.