Comparison of Immunological Abnormalities of Lymphocytes in Bone Marrow in Myelodysplastic Syndrome (MDS) and Aplastic Anemia (AA)
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概要
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Objective The subsets and the polarization of lymphocytes in bone marrow from low-risk myelodysplastic syndrome (MDS) were studied and compared with those from patients with aplastic anemia (AA). Methods A total of 34 patients with low-risk MDS (IPSS score≤1.0) who presented abnormal chromosomes and 16 patients with AA were enrolled in this study. We determined T lymphocyte subsets, T cells polarization status, and the percentages of NK cells and of B lymphocytes in bone marrow and compared these parameters between the two groups of patients. As controls, 24 patients with high-risk MDS (IPSS score>1.0) presenting abnormal chromosomes and 22 healthy/benign hematologic disease subjects were used. Results In low-risk MDS/AA patients, the percentage of CD3+ lymphocytes was significantly increased compared to controls (p=0.006 and p=0.001), while the percentage of CD19+ lymphocytes was significantly decreased (p<0.001 and p=0.002); there were no significant differences between MDS/AA and normal controls in other parameters; For low-risk MDS patients, the polarization status of bone marrow CD4+ cells toward Th1 (Th1/Th2) and of CD8+ cells toward Tc1 (Tc1/Tc2) was stronger than that for AA patients (p=0.05 and p<0.001). Other parameters did not show significant differences; Regardless of the predominance of CD4 or CD8 T cells, all patients with low-risk MDS were accompanied with elevated Tc1 polarization (Tc1/Tc2). Conclusion In both AA and MDS, the number of total T lymphocytes increased. However, polarization towards Th1 and Tc1 was obviously stronger in MDS patients than in AA patients. This might be related to T cell stimulation from the clones of malignant hematopoietic cells.
著者
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Xu Feng
Department Of Applied Chemistry Okayama University Of Science
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Chang Chunkang
Department Of Hematology Sixth Hospital Affiliated To Shanghai Jiaotong University
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Wu Lingyun
Department Of Hematology Sixth Hospital Affiliated To Shanghai Jiaotong University
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Zhang Zheng
Department Of Materials Physics State Key Laboratory For Advanced Metals And Materials University Of Science And Technology Beijing
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Li Xiao
Department of Cardiology, West China Hospital, Sichuan University, Sichuan Province, China
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Xu Feng
Department of Hematology, Sixth Hospital Affiliated to Shanghai Jiaotong University
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He Qi
Department of Hematology, Sixth Hospital Affiliated to Shanghai Jiaotong University
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Zhang Zheng
Department of Hematology, Sixth Hospital Affiliated to Shanghai Jiaotong University
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