医科学への応用を目的としたサル類の発生工学的研究

概要

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Since non-human primates are closely related to human and share many physical similarities, they are important for use in translational research from basic research. The study of non-human primates has contributed to our understanding of basic biological phenomena such as reproduction; diseases and the development of drugs, treatment and vaccines for the promotion of better health for human and non-human primate alike. A lot of researches are obtained basic data from rodents such as mouse. However, even if the results are directly applied to human clinical situations, new generation therapeutics in reproduction are often so specific and cannot be predicted by testing in rodents. Often these important side effects can only be detected in specific primate models. The close genetic, immunological and virological relation with human makes non-human primates an excellent model of diseases. Therefore, primate research for medical science is conducted and the formation of the breeding colonies for this purpose is recognized to be great importance. It is necessary to pay attention to developmental study on reproduction field for the reproductive medicine and regenerative medicine. In this paper, I describe the current state of this research and the problems of developmental reproductive technology in the non-human primate.