ビタミンCの欠乏はマウスマラリア抵抗性を誘導しない
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概要
- 論文の詳細を見る
Nutritional deficiencies are frequent in malaria-endemic areas. It seems that micronutrient antioxidants play an important role in malaria parasite’s proliferation. Thus, the effect of vitamin C deficiency on malaria infection was examined in mice. When vitamin C deficient mice, L-gulono-γ-lactone oxidase gene knockout mice which are unable to synthesize ascorbic acid, were infected with a lethal dose of Plasmodium berghei NK65-infected red blood cells, the knockout mice showed similar parasitemia kinetics and survival rates as wild-type mice. The results indicate that deficiency of vitamin C might not affect the development of the malaria parasite in mice.
著者
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Herbas Maria
Research Unit for Functional Genomics, National Research Center for Protozoan Diseases, Obihiro Univ
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鈴木 宏志
Research Unit for Functional Genomics, National Research Center for Protozoan Diseases, Obihiro Univ
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Suzuki Hiroshi
Research Group For Neutron Scattering From Functional Materials Neutron Science Research Center Japa
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