Variation in the Frequency of Micronucleated Hepatocytes Following Time Course Treatment in the Mouse : Liver Micronucleus Assay of Partially Hepatectomized Tissues
スポンサーリンク
概要
- 論文の詳細を見る
The time-course pattern of the frequency of micronucleated hepatocytes in vivo after partial hepatectomy (PH) was studied in mice using N-nitrosodimethylamine (DMN), N-nitrosodiethylamine (DEN), and 1,2-dimethylhydrazine (DMH), which are rodent liver carcinogens with potent clastogenic activity in the liver. With all chemicals, production of micronucleated hepatocytes was not clearly observed at 3 d after PH, but was clear 4 or 5 d after PH. We propose that it is preferable to perform a preliminary assay prior to the main assay when estimating the clastogenic potential of certain chemicals towards hepatocytes in vivo.
- 公益社団法人日本薬学会の論文
- 2000-08-01
著者
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SUZUKI Hiroshi
Research Unit for Functional Genomics, National Research Center for Protozoan Diseases, Obihiro Univ
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Suzuki H
Research Center Taisho Pharmaceutical Co. Ltd.
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OHSAWA Koh-ichi
Research Center, Taisho Pharmaceutical Co., Ltd.,
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HIRANO Noriko
Research Center, Taisho Pharmaceutical Co., Ltd.,
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HIRASHIO Toshiko
Research Center, Taisho Pharmaceutical Co., Ltd.,
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KIMURA Msaaki
Research Center, Taisho Pharmaceutical Co., Ltd.,
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Ohsawa Koh-ichi
Research Center Taisho Pharmaceutical Co. Ltd.
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Suzuki Hiroshi
Research Group For Neutron Scattering From Functional Materials Neutron Science Research Center Japa
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Hirano Noriko
Research Center Taisho Pharmaceutical Co. Ltd.
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Kimura Msaaki
Research Center Taisho Pharmaceutical Co. Ltd.
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Hirashio Toshiko
Research Center Taisho Pharmaceutical Co. Ltd.
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Suzuki Hiroshi
Research Center, Taisho Pharmaceutical Co., Ltd.,
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