Pediococcus pentosaceus Sn26 Inhibits IgE Production and the Occurrence of Ovalbumin-Induced Allergic Diarrhea in Mice

スポンサーリンク

概要

• 論文の詳細を見る

• We investigated the anti-allergic effect of a new strain (Pediococcus pentosaceus Sn26, the Sn26 strain) among 59 strains isolated from Japanese fermented vegetable pickles, the Sunki pickle. The Sn26 strain increased Th1 type cytokine (IL-12 and IFN-γ) production of Peyer’s patch (PP) cells in BALB/c mice, improved the Th1/Th2 balance, and inhibited IgE production of splenocytes of ovalbumin (OVA)-induced allergic diarrheic mice. Next we demonstrated, by neutralizing IL-12 and IFN-γ, that the Sn26 strain first induced IL-12, that IL-12 induced IFN-γ, and that decreases in IL-4 and IgE production followed. Furthermore, oral administration of the Sn26 strain decreased serum OVA-specific IgE levels and ameliorated the appearance of diarrhea in OVA-induced allergic diarrheic mice. Based on these results, it was assumed that oral administration of the Sn26 strain ameliorated type-1 allergies through improvement of the Th1/Th2 balance and decreases in IgE production.

• 社団法人 日本農芸化学会の論文

著者

• Okada Sanae

  Culture Collection Center Tokyo University Of Agriculture

• Masuda Takeyuki

  Sciences of Functional Foods, Graduate School of Agriculture, Shinshu University

• Kimura Makoto

  Sciences of Functional Foods, Graduate School of Agriculture, Shinshu University

• YASUI Hisako

  Sciences of Functional Foods, Graduate School of Agriculture, Shinshu University

関連論文

• Identification and Characteristics of Lactic Acid Bacteria Isolated from Sour Dough Sponges
• Pediococcus pentosaceus Sn26 Inhibits IgE Production and the Occurrence of Ovalbumin-Induced Allergic Diarrhea in Mice
• 3S3-AM5 Plant Origin Lactic Acid Bacteria in Indigenous Fermented Foods in Japan
• Immunomodulatory Function and Probiotic Properties of Lactic Acid Bacteria Isolated from Mongolian Fermented Milk
• Effects of Hop Water Extracts on Hemagglutination Reaction of Influenza A Virus and Influenza A Virus-Induced Mortality in Mice
• Oral Administration of Heat-Killed Lactobacillus brevis SBC8803 Ameliorates the Development of Dermatitis and Inhibits Immunoglobulin E Production in Atopic Dermatitis Model NC/Nga Mice(Pharmacology)
• Pediococcus pentosaceus Sn26 Inhibits IgE Production and the Occurrence of Ovalbumin-Induced Allergic Diarrhea in Mice
• Tetragenococcus halophilus MN45 Isolated from Miso Inhibits IgE Production
• Tetragenococcus halophilus MN45 Ameliorates Development of Atopic Dermatitis in Atopic Dermatitis Model NC/Nga Mice

スポンサーリンク