Modulation of Neuroprotective Effect of Ischemic Post-Conditioning by Dichlorobenzamil a Na+/Ca2+ Exchanger Inhibitor in Mice
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概要
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The present study has been designed to investigate the modulatory role of dichlorobenzamil a Na+/Ca2+ exchanger inhibitor in ischemic post-conditioning-induced neuroprotection in mice. Bilateral carotid artery occlusion followed by reperfusion, produced a significant rise in cerebral infarct size along with impairment of memory and motor coordination. Ischemic post-conditioning involving three episodes of 10 s carotid artery occlusion with intermittent reperfusion of 10 s proceeding prolonged ischemic insult of 12 min, produced a significant decrease in cerebral infarct size along with reversal of ischemia-reperfusion-induced impairment of memory and motor coordination. Ischemic post-conditioning-induced neuroprotective effects were significantly abolished by pretreatment with dichlorobenzamil (DBZ 0.5, 1 mg/kg, intraperitoneal) a Na+/Ca2+ exchange inhibitor. It may be concluded that Na+/Ca2+ exchanger possibly plays an important role in ischemic post-conditioning-induced neuroprotection.
- 公益社団法人 日本薬学会の論文
著者
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Jaggi Amteshwar
Department of Pharmaceutical Sciences and Drug Research, Punjabi University
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Singh Nirmal
Department of Pharmaceutical Sciences and Drug Research, Punjabi University
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Jaggi Amteshwar
Department Of Pharmaceutical Sciences And Drug Research Punjabi University
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Kaur Hardeep
Department of Pharmaceutical Sciences and Drug Research, Punjabi University
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Singh Nirmal
Department Of Pharmaceutical Sciences & Drug Research Punjabi University
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