Possible Role of Opioids and K_<ATP> Channels in Neuroprotective Effect of Postconditioning in Mice(Pharmacology)
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概要
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The present study was designed to investigate the possible role of opioids and K_<ATP> channels in ischemic postconditioning-induced reversal of global cerebral ischemia and reperfusion (I/R) induced neuronal injury. Mice were subjected to global ischemia by bilateral carotid artery occlusion for 10min followed by reperfusion for 24h, to produce neuronal injury. Ischemic postconditioning was induced by three episodes of carotid artery occlusion and reperfusion of 10s each, immediately after global ischemia. Morphine postconditioning was induced by administration of morphine (5mg/kg i.v.), 5min prior to reperfusion. Naloxone (5mg/kg i.v.), opioid receptor antagonist, and glibenclamide (5mg/kg i.v.), K_<ATP> channel blocker were administered 10min before global ischemia. Extent of cerebral injury was assessed by measuring cerebral infarct size using triphenyl tetrazolium chloride (TTC) staining. Short-term memory was evaluated using the elevated plus maze test, while degree of motor incoordination was evaluated using inclined beam-walking, rota-rod and lateral push tests. Bilateral carotid artery occlusion followed by reperfusion resulted in significant increase in infarct size, impairment in short-term memory and motor co-ordination. Ischemic/morphine postconditioning significantly attenuated I/R induced neuronal injury and behavioural alterations. Pretreatments with naloxone and glibenclamide attenuated the neuroprotective effects of ischemic/morphine postconditioning. It may be concluded that ischemic/morphine postconditioning protects I/R induced cerebral injury via activating opioid receptor and K_<ATP> channel opening.
- 公益社団法人日本薬学会の論文
- 2008-09-01
著者
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Jaggi Amteshwar
Department of Pharmaceutical Sciences and Drug Research, Punjabi University
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Singh Nirmal
Department of Pharmaceutical Sciences and Drug Research, Punjabi University
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Singh Nirmal
Department Of Pharmaceutical Sciences And Drug Research Punjabi University
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Jaggi Amteshwar
Department Of Pharmaceutical Sciences And Drug Research Punjabi University
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PATELIYA Bharat
Department of Pharmaceutical Sciences and Drug Research, Punjabi University
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Pateliya Bharat
Department Of Pharmaceutical Sciences And Drug Research Punjabi University
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Singh Nirmal
Department Of Pharmaceutical Sciences & Drug Research Punjabi University
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