Thalidomide Attenuates Airway Hyperresponsiveness and Eosinophilic Inflammation in a Murine Model of Allergic Asthma
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概要
- 論文の詳細を見る
Asthma is characterized by chronic eosinophilic inflammation and hyperresponsiveness of the airways. We hypothesized that thalidomide, which has numerous immunomodulatory properties, may have anti-inflammatory effects in allergic asthma. BALB/c mice sensitized and challenged with ovalbumin (OVA) were treated orally with thalidomide (30, 100, or 300 mg/kg) or a vehicle. When thalidomide was administered to OVA-challenged mice, the number of eosinophils in bronchoalveolar lavage fluid (BALF) was significantly decreased. The numbers of inflammatory cells other than eosinophils were not reduced by thalidomide. Thalidomide inhibited the elevated levels of interleukin-5 (IL-5) and tumor necrosis factor-α (TNF-α) in BALF by OVA challenges. Histological analysis of the lung revealed that both the infiltration of inflammatory cells and the hyperplasia of goblet cells were significantly suppressed by thalidomide treatment. Furthermore, thalidomide significantly inhibited the response to methacholine induced by OVA challenges. Taken together, thalidomide treatment decreased airway inflammation and hyperresponsiveness in a murine model of allergic asthma. These results might provide an opportunity for the development of novel therapeutics to treat severe asthma.
- 公益社団法人 日本薬学会の論文
著者
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Kume Hiroaki
Department Of Chemistry School Of Science And Engineering Kinki University
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Hasegawa Yoshinori
Department Of Biological Mechanisms And Functions Graduate School Of Bioagricultural Sciences Nagoya
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Ito Satoru
Department Of Biomedical Engineering Boston University
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Asano Toshiaki
Department of Respiratory Medicine, Nagoya University Graduate School of Medicine
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Taki Fumitaka
Department of Respiratory Medicine, Nagoya University Graduate School of Medicine
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Kume Hiroaki
Department of Respiratory Medicine, Nagoya University Graduate School of Medicine
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