Pulmonary Infectious Complications Associated with Anti-TNF.ALPHA. Therapy (Infliximab) for Rheumatoid Arthritis
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概要
- 論文の詳細を見る
Two patients with rheumatoid arthritis (RA) that developed serious infectious complications following anti-TNFα therapy (infliximab) are reported. Patient 1 developed tuberculosis with high fever, refractory diarrhea and mediastinal lymphadenopathy. Trans-bronchial needle biopsy was useful to confirm the diagnosis. Patient 2 showed sudden onset of dyspnea with diffuse bilateral lung infiltration caused by pneumocystis jiroveci pneumonia and the diagnosis was confirmed by broncho-alveolar lavage. Physicians should be alerted to infectious complications with atypical presentation and rapid progression in infliximab-treated patients. Invasive diagnostic procedures including fiber-optic bronchoscopy may be necessary early in the course for such cases.
- 社団法人 日本内科学会の論文
著者
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Hasegawa Yoshinori
Department Of Biological Mechanisms And Functions Graduate School Of Bioagricultural Sciences Nagoya
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Imaizumi Kazuyoshi
Department Of Respiratory Medicine Nagoya University Graduate School Of Medicine
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Hashimoto Naozumi
Department of Respiratory Medicine, Nagoya University Graduate School of Medicine
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Sugishita Mihoko
Department of Respiratory Medicine, Nagoya University Graduate School of Medicine
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Kawabe Tsutomu
Department of Medical Technology, Nagoya University Graduate School of Health Science
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Usui Miho
Department of Respiratory Medicine, Nagoya University Graduate School of Medicine
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