Coronary Plaque Regression and Lifestyle Modification in Patients Treated With Pravastatin : – Assessment Mainly by Daily Aerobic Exercise and an Increase in the Serum Level of High-Density Lipoprotein Cholesterol –
スポンサーリンク
概要
- 論文の詳細を見る
Background: The purpose of this study was to explore the effect of lifestyle modification, mainly daily aerobic exercise, on coronary atherosclerosis in patients with coronary artery disease (CAD). Methods and Results: A 6-month prospective observational study was conducted with 84 CAD patients receiving pravastatin treatment in order to evaluate the relationship between lifestyle modification, in particular aerobic exercise, and plaque volume as assessed by intravascular ultrasound (IVUS). Lifestyle during the study period was assessed by the-lifestyle modification score. A significant decrease in plaque volume by 12.9% was observed after 6 months of pravastatin therapy (P<0.0001 vs baseline). The change in plaque volume correlated with the change in the serum level of high-density lipoprotein cholesterol (HDL-C) (r=-0.549, P<0.0001), non-HDL-C (r=0.248, P=0.03), low-density lipoprotein cholesterol/HDL-C (r=0.505, P<0.0001), apolipoprotein (apo) A-1 (r=-0.335, P=0.007) and apoB/apoA-1 (r=0.335, P=0.007), and lifestyle modification score (r=-0.616, P<0.0001). There was a clear positive correlation between a change in the serum HDL-C level and lifestyle modification score. Multivariate regression analysis revealed that the increase in serum HDL-C level and lifestyle modification score were independent predictors of coronary plaque regression. Conclusions: An appropriate combination of statin therapy and lifestyle modification, in particular, physical activity, may result in coronary plaque regression. This combined treatment strategy, inducing an increase of the serum HDL-C, may contribute to coronary plaque regression. (Circ J 2010; 74: 954 - 961)
著者
-
HIRAYAMA Atsushi
Division of Cardiology, Department of Medicine, Nihon University School of Medicine
-
Nagao Ken
Department of Cardiology, Nihon University Surugadai Hospital
-
Takahashi Hiroshi
Department of Cardiology, Nagoya Kyoritsu Hospital
-
Tani Shigemasa
Departments of Cardiology
-
Anazawa Takeo
Department of Cardiology, Nihon University Surugadai Hospital
-
Kawamata Hirofumi
Department of Cardiology, Nihon University Surugadai Hospital
-
Matsumoto Michiaki
Department of Cardiology, Surugadai Nihon University Hospital
-
Washio Takehiko
Department of Cardiology, Kawaguchi Municipal Medical Center
-
Kumabe Narimichi
Department of Cardiology, Nihon University Surugadai Hospital
-
Iida Kiyoshi
Department of Cardiology, Nihon University Surugadai Hospital
-
Furuya Shingo
Department of Cardiolugy, Nihon University Surugadai Hospital
関連論文
- Coronary Plaque Regression and Lifestyle Modification in Patients Treated With Pravastatin : – Assessment Mainly by Daily Aerobic Exercise and an Increase in the Serum Level of High-Density Lipoprotein Cholesterol –
- Comparison of Endocardial and Epicardial Lesion Size Following Large-Tip and Extra-Large-Tip Transcatheter Cryoablation
- Abnormal Action Potential Duration Restitution Property in the Right Ventricular Outflow Tract in Brugada Syndrome
- Right Ventricular Histological Substrate and Conduction Delay in Patients With Brugada Syndrome
- Non-Invasive Assessment and Clinical Strategy of Stable Coronary Artery Disease by Magnetic Resonance Imaging, Multislice Computed Tomography and Myocardial Perfusion SPECT
- PJ-717 What is the Most Reluctance to Undertake Basic Life Support and AED? : Survey of 1,445 Citizens Receiving BLS & AED Training Course(PJ120,Cardiopulmonary and Critical Care/ACLS (H),Poster Session (Japanese),The 73rd Annual Scientific Meeting of The
- OE-338 The properties of neointima after the drug-eluting stent (Cypher and Taxus) implantation : Observed by IVUS, Angioscopy and OCT at follow-up study(OE57,Intravascular Imagings (I),Oral Presentation (English),The 73rd Annual Scientific Meeting of The
- Temperature-Controlled Cooled-Tip Radiofrequency Ablation in Left Ventricular Myocardium : Avoidance of Steam Pop During Ablation
- PJ-144 Efficacy of Low Level Laser Therapy around the Stellate Ganglion in the Treatment of Sick Sinus Syndrome(PJ024,Arrhythmia, Others (Clinical/Diagnosis/Treatment) 1 (A),Poster Session (Japanese),The 73rd Annual Scientific Meeting of The Japanese Circ
- PJ-003 The Characteristics of Ventricular Tachyarrhythmia Associated with a High Incidence of Isolated Left Ventricular Non-compaction(PJ001,Arrhythmia, Others (Clinical/Pathophysiology) 1 (A),Poster Session (Japanese),The 73rd Annual Scientific Meeting o
- Incremental Prognostic Value of Cardiac Function Assessed by ECG-Gated Myocardial Perfusion SPECT for the Prediction of Future Acute Coronary Syndrome
- PJ-139 Investigation of Neointimal Coverage Grading and Yellow Plaque Grading in Stent Site after Sirolimus- Eluting Stent Implantation : angioscopic finding(Intravascular endoscopy/Intravascular ultrasound(05)(I),Poster Session(Japanese),The 72nd Annual
- 1 The detection of vulnerable plaque by intravascular ultrasound : Comparison of intravasclar ultrasound and angioscopy findings(The pathogenesis and preventive strategy for DES failure : Evaluation by invasive coronary imaging modalities,Roundtable Discu
- 1 Can intravascular ultrasound detect the plaque rupture preceding acute coronary stndrome? : Comparison of intravasclar ultrasound and angioscopy findings(Can we predict the onset of acute coronary syndrome?,Controversy (C-1) (I),Special Program,The 72nd
- Qualitative and Quantitative Changes in Coronary Plaque Associated With Atorvastatin Therapy
- PE-270 Plaque Stabilization and Regression by Lipid Lowering Therapy in Patients With Coronary Heart Disease(Atherosclerosis, clinical(06)(IHD),Poster Session(English),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
- PJ-128 The effecacy of Shock Wave Treatment for Angina Pectoris Patients Post-bypass Surgery(PJ022,Coronary Revascularization, PCI (New Devices/New Technology) 1 (IHD),Poster Session (Japanese),The 73rd Annual Scientific Meeting of The Japanese Circulatio
- OE-338 The properties of neointima after the drug-eluting stent (Cypher and Taxus) implantation : Observed by IVUS, Angioscopy and OCT at follow-up study(OE57,Intravascular Imagings (I),Oral Presentation (English),The 73rd Annual Scientific Meeting of The
- Mismatch Between Results of Myocardial Fractional Flow Reserve (FFR) Measurements and Myocardial Perfusion SPECT for Identification of the Severity of Ischemia : Pitfall of FFR in Patients With Prior Myocardial Infarction
- PJ-413 Long-term Effect of Standard Right Atrial Ablation for Atrioventricular Nodal Reentry with Earliest Activation in the Coronary Sinus(Arrhythmia, therapy-22, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- Effect of Rosuvastatin on Coronary Atheroma in Stable Coronary Artery Disease : Multicenter Coronary Atherosclerosis Study Measuring Effects of Rosuvastatin Using Intravascular Ultrasound in Japanese Subjects (COSMOS)
- PJ-084 Prevalence and Clinical Significance of Dobutamine-Induced Left Ventricular Outflow Tract Obstruction in Symptomatic Patients with Non-Obstructive Hypertrophic Cardiomyopathy(PJ014,Cardiomyopathy/Hypertrophy (Clinical) (M),Poster Session (Japanese)
- PJ-405 Drug Eluting Stent (DES) for Acute Myocardial Infarction (AMI) in Patients with Diabetes Mellitus (DM)(PJ068,Coronary Revascularization, PCI (DES) 2 (IHD),Poster Session (Japanese),The 73rd Annual Scientific Meeting of The Japanese Circulation Soci
- PJ-725 Safety and Efficacy of Sirolimus-Eluting Stent (SES) in Patients with Acute Coronary Syndrome (ACS) in Emergent Procedure(Coronary revascularization, PCI-17, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- PJ-496 Plasma Homocysteine and Risk for Congestive Heart Failure in Patients with Acute Myocardial Infarction(Heart failure, clinical-14, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- PE-001 Increasingly Well preserved Left Ventricular Function in Hospital Survivors with Acute Myocardial Infarction : Evaluation by Advancement of Reperfusion Therapy(Acute myocardial infarction, clinical (diagnosis/treatment)-4, The 71st Annual Scientifi
- OE-261 Mechanism of Prevention of Cardiac Events by Angiotensin-converting Enzyme Inhibitors and Angiotensin Receptor Blockers in High-risk Myocardial Infarction Patients(Acute myocardial infarction, clinical (diagnosis/treatment)-1, The 71st Annual Scien
- PJ-778 Statin-Induced Improvement of Lipid Metabolism Leading to Decreased Oxidative Stress Attenuates Vasoconstrictivity in Patients with Vasospastic Angina(Myocardial ischemia-reperfusion, basic/clinical-6 (IHD) PJ136,Poster Session (Japanese),The 70th
- PJ-636 Lower Baseline Body Mass Index is a Predictor of Coronary Atherosclerosis Regression before Statin Treatment : A Six-month Prospective Study(Atherosclerosis, clinical-13 (H) PJ107,Poster Session (Japanese),The 70th Anniversary Annual Scientific Mee
- PJ-486 HDL Cholesterol is Associated with Coronary Plaque Regression in 'Good HDL Cholesterol Responders to Statins' : A Six-month Prospective Study(Atherosclerosis, clinical-12 (H) PJ82,Poster Session (Japanese),The 70th Anniversary Annual Scientific Mee
- OJ-367 Synergistic Effect of Pravastatin and Amlodipine on Coronary Atherogenesis : Evaluation by 3-Dimensional Intravascular Ultrasound and Malondialdehyde-Modified Low-Density Lipoprotein Levels(Atherosclerosis, clinical-5 (H) OJ62,Oral Presentation (Ja
- Effect of Pioglitazone on Arteriosclerosis in Comparison with That of Glibenclamide (Cardiovascular Pharmacology, Basic/Clinical 3 (H), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- Serum Levels of Apolipoprotein A-I Predict Atherosclerotic Plaque Volume at Vasospasm Site in Angiographically Near-Normal Coronary Arteries(Atherosclerosis, Clinical 2 (IHD), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- Comparison of the Effects of Losartan and Enalapril on Ventricular Remodeling and Long-Term Prognosis after Acute Myocardial Infarction(Old Myocardial Infarction/Remodeling 1 (IHD), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- Coronary Plaque Regression and Lifestyle Modification in Patients Treated With Pravastatin : Assessment Mainly by Daily Aerobic Exercise and an Increase in the Serum Level of High-Density Lipoprotein Cholesterol
- Abnormal Action Potential Duration Restitution Property in the Right Ventricular Outflow Tract in Brugada Syndrome
- 6 Results of Coronary Atherosclerosis Study Measuring Effects of Rosuvastatin Using Intravascular Ultrasound in Japanese Subjects (COSMOS)(Late Breaking Clinical Trials II,The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
- Non-Invasive Assessment and Clinical Strategy of Stable Coronary Artery Disease by Magnetic Resonance Imaging, Multislice Computed Tomography and Myocardial Perfusion SPECT
- PJ-522 The Measurement of Plasma Arginine Vasopressin (AVP) on Admission in Patients Presenting with ST-Elevation Myocardial Infarction(STEMI)(PJ088,ACS/AMI (Clinical/Pathophysiology) 2 (IHD),Poster Session (Japanese),The 73rd Annual Scientific Meeting of
- PJ-417 Combined Use of Ensite Non-Contact Mapping System and Template Matching for Radiofrequency Catheter Ablation of Right Ventricular Outflow Tract Tachycardia(PJ070,Ventricular Arrhythmia (Clinical/Diagnosis/Treatment) 1 (A),Poster Session (Japanese),
- PJ-011 The Upper Turnover Site in the Reentry Circuit of Common Atrial Flutter-3 Dimensional Mapping and Entrainment Study(PJ002,Atrial/Supraventricular Arrhythmia (Clinical/Pathophysiology) (A),Poster Session (Japanese),The 73rd Annual Scientific Meeting
- PE-489 Idiopathic Ventricular Fibrillation Presenting with Prominent J Wave(PE082,Ventricular Arrhythmia (Clinical/Diagnosis/Treatment) (A),Poster Session (English),The 73rd Annual Scientific Meeting of the Japanese Circulation Society)
- Abnormal Atrial Repolarization and Depolarization Contribute to the Inducibility of Atrial Fibrillation in Brugada Syndrome
- Effects of Enalapril and Losartan in Left Ventricular Remodeling after Acute Myocardial Infarction: A Possible Mechanism of Prevention of Cardiac Events by Angiotensin-converting Enzyme Inhibitors and Angiotensin Receptor Blockers in High-risk Myocardial
- Surface ECG Characteristics of Ventricular Tachyarrhythmias Before Degeneration Into Ventricular Fibrillation in Patients With Brugada-Type ECG
- Use of a Novel Irrigated Balloon Catheter to Generate Continuous Right Atrial Lesions by Radiofrequency Ablation
- Idiopathic Ventricular Fibrillation Characterized by Spatial Heterogeneity of Action Potential Duration and Its Restitution Kinetics
- Combined Effect of Pulmonary Vein Isolation and Ablation of Cardiac Autonomic Nerves for Atrial Fibrillation
- PJ-176 The efficacy of cell therapy for ischemic cardiomyopathy using a retrograde injection method through coronary vein with a novel catheter(Regeneration(angiogenesis/myocardial regeneration)(04)(M),Poster Session(Japanese),The 72nd Annual Scientific M
- OJ-215 Can VH-IVUS detect vulnerable plaque in non-culprit lesion in patients with acute coronary syndrome? : comparison with angloscopyic flndlngs(Acute coronary syndrome, basic / clinical(02)(IHD),Oral Presentation (Japanese),The 72nd Annual Scientific
- OE-244 Efficacy of HDL-C increase for continuing plaque regression in late period with atorvastatin treatment : Results from TWINS study(Chronic coronary heart disease/Remodeling(01)(IHD),Oral Presentation(English),The 72nd Annual Scientific Meeting of th
- OJ-101 Magnetic Resonance Imaging Detects Chronic Left Atrial Wall Injury Post Ablation of Atrial Fibrillation(OJ17,Atrial/Supraventricular Arrhythmia (Clinical/Treatment) (A),Oral Presentation (Japanese),The 73rd Annual Scientific Meeting of The Japanese
- P Wave Morphology of an Arrhythmogenic Focus in Patients With Atrial Fibrillation Originating From a Pulmonary Vein or the Superior Vena Cava
- PJ-785 Novel Imaging Technique of the Pulmonary Veins, Left atrium and Esophagus for Enhancing Safety of Left Atrial Ablation(Arrhythmia, therapy(17)(A),Poster Session(Japanese),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
- PJ-774 Surface and Intracardiac Electrogram Characteristics of Induced Ventricular Tachyarrhythmias before Degenerating into Ventricular Fibrillation in Brugada Syndrome(Arrhythmia, diagnosis / Pathophysiology / EPS(11)(A),Poster Session(Japanese),The 72n
- PJ-023 Endocardial Impedance Mapping during Pulmonary Vein Isolation of Atrial Fibrillation(Arrhythmia, diagnosis/Pathophysiology/EPS(12)(A),Poster Session(Japanese),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
- PE-253 Electroanatomical Mapping of the right ventricle in Patients with the Brugada Syndrome(Arrhythmia, diagnosis/Pathophysiology/EPS(07)(A),Poster Session(English),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
- Endocardial Electrograms From the Right Ventricular Outflow Tract After Induced Ventricular Fibrillation in Patients With Brugada Syndrome
- 1 Why Do We Select Percutaneous Coronary Intervention to Three-vessel Disease?(Therapeutic Strategy for Three-vessel Coronary Artery Disease -OPCAB vs. PCI-,Controversy 2 (C-2) (IHD),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
- PJ-850 Result Messages from Portable ECG Monitoring Devices for Home Use are Appropriate Enough for Users?(ECG / Body surface potential mapping / Holter(07)(A),Poster Session(Japanese),The 72nd Annual Scientific Meeting of the Japanese Circulation Society
- PE-319 The Natural Longevity of the Uygur People in the Western Region of China Has Less Chance to Have Atrial Fibrillation?(ECG/Body surface potential mapping/Holter(04)(A),Poster Session(English),The 72nd Annual Scientific Meeting of the Japanese Circul
- PE-083 Velocity Vector Imaging Derived Phase Analysis of Circumferential Strain Accurately Identifies Patients with Left Ventricular Dyssynchrony(Echo/Doppler(05)(I),Poster Session(English),The 72nd Annual Scientific Meeting of the Japanese Circulation So
- OE-103 The interaction between atrial natriuretic peptide and heart rate variability in human subjects(Autonomic nervous system(01)(H),Oral Presentation(English),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
- The Plaque Color of the Culprit Lesion with Angioscopy is Associated with Lp(a) (Intravascular Endoscopy/Intravascular Ultrasound 2 (I), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- Temperature-Controlled Cooled-Tip Radiofrequency Linear Ablation of the Atria Guided by a Realtime Position Management System
- Transition From Asymptomatic Diastolic Dysfunction to Heart Failure With Preserved Ejection Fraction : – Roles of Systolic Function and Ventricular Distensibility –
- Diagnostic Value of Adenosine-Induced Left Ventricular Diastolic Dysfunction for Detecting Coronary Artery Restenosis in Patients Undergoing Stent Implantation by Stress ECG-Gated Myocardial Perfusion SPECT : – A Pilot Study –
- Lesion Formation by Ventricular Septal Ablation With Irrigated Electrodes : – Comparison of Bipolar and Sequential Unipolar Ablation –
- Electrical Remodeling in Fibrillating Canine Atrium : Action Potential Alternans During Rapid Atrial Pacing and Late Phase 3 Early Afterdepolarization After Cessation of Rapid Atrial Pacing
- Renin-Angiotensin System in the Brain as a New Target of Antihypertensive Therapy
- OE-057 Role of Kynurenine Aminotransferase-1 (KAT-1) Gene in Rostral Ventrolateral Medulla (RVLM) on Salt-sensitive hypertension (SSH).(Hypertension, basic(01)(H),Oral Presentation(English),The 72nd Annual Scientific Meeting of the Japanese Circulation So
- PJ-674 Dose Obesity Attenuate Anti-atherosclerotic Effects of Statin on Coronary Atherosclerosis? : 6-month Prospective Study(Diabetes / Obesity / Metabolic syndrome(13)(H),Poster Session(Japanese),The 72nd Annual Scientific Meeting of the Japanese Circul
- OJ-225 Relation of Coronary Vasospasm with High-sensitivity C-reactive Protein Level : Implication of Acute Coronary Events Caused by Focal Vasospasm(Angina pectoris, basic / clinical(02)(IHD),Oral Presentation (Japanese),The 72nd Annual Scientific Meetin
- OJ-153 The Change in the Apolipoprotein B/Apolipoprotein A-1 Ratio is an Independent Predictor for Coronary Atherosclerosis Regression : 6-month Prospective Studty(Preventive medicine / Epidemiology / Education(02)(H),Oral Presentation (Japanese),The 72nd
- Is Angioplasty Able to Become the Gold Standard of Treatment Beyond Bypass Surgery for Patients With Multivessel Coronary Artery Disease? : – Therapeutic Strategies for 3-Vessel Coronary Artery Disease: OPCAB vs PCI (PCI-Side) –
- Association of Body Mass Index with Coronary Plaque Regression : 6-Month Prospective Study
- Three-Dimensional Reconstruction of the Coronary Sinus With Rotational Angiography
- OJ-046 Impact of Increased Hign-density Lipoprotein Cholesterol Level by Combination Therapy with Pravastatin and Lifestyle Modification on Coronary Atherosclerosis Regression(Atherosclerosis, clinical(03)(IHD),Oral Presentation(Japanese),The 72nd Annual
- 3 Can We Predict the Onset of Acute Coronary Syndrome?(Should Drug Eluting Stents be Indicated for the Patients with Acute Coronary Syndrome?,Controversy 3 (C-3) (IHD),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
- Action Potential Alternans in the Right Ventricular Outflow Tract in a Patient With Asymptomatic Brugada Syndrome
- 4 Plaque Stabilization and Regression by Lipid Lowering Therapy in Japanese Patients With Coronary Heart Disease(Symposium 18 (SY-18) (H) How can we Make the Best Use of Japanese Evidences for Future Guidelines,Special Program,The 72nd Annual Scientific M
- SILENT ISCHEMIA DURING CORONARY OCCLUSION PRODUCED BY BALLOON INFLATION : RELATION TO LACTATE METABOLISM : Ischemic Heart Disease : 53 Annual Scientific Meeting, Japanese Circulation Society
- Topics in Nuclear Cardiology(Topics in Nuclear Cardiology(I),Featured Research Session,The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
- Stabilization and Regression of Coronary Plaques Treated With Pitavastatin Proven by Angioscopy and Intravascular Ultrasound : The TOGETHAR Trial
- Combined Assessment of Myocardial Perfusion and Function by ECG-Gated Myocardial Perfusion Single-Photon Emission Computed Tomography for the Prediction of Future Cardiac Events in Patients With Type 2 Diabetes Mellitus
- Diagnostic Value of Adenosine-Induced Left Ventricular Diastolic Dysfunction for Detecting Coronary Artery Restenosis in Patients Undergoing Stent Implantation by Stress ECG-Gated Myocardial Perfusion SPECT : A Pilot Study
- Is Angioplasty Able to Become the Gold Standard of Treatment Beyond Bypass Surgery for Patients With Multivessel Coronary Artery Disease? : Therapeutic Strategies for 3-Vessel Coronary Artery Disease : OPCAB vs PCI (PCI-Side)
- Transition From Asymptomatic Diastolic Dysfunction to Heart Failure With Preserved Ejection Fraction : Roles of Systolic Function and Ventricular Distensibility
- Lesion Formation by Ventricular Septal Ablation With Irrigated Electrodes : Comparison of Bipolar and Sequential Unipolar Ablation
- Plaque-Stabilizing Effect of Atorvastatin Is Stronger for Plaques Evaluated as More Unstable by Angioscopy and Intravenous Ultrasound
- Less Invasive Approach to the Assessment of Coronary Artery Disease : Morphological vs. Physiological Paradigm
- Effects of Quinidine on the Action Potential Duration Restitution Property in the Right Ventricular Outflow Tract in Patients With Brugada Syndrome
- Myocardial Protective Effect of Human Atrial Natriuretic Peptide in Cardiac Surgery : "hANP Shot" in Clinical Safety Trial
- Reverse Vessel Remodeling But Not Coronary Plaque Regression Could Predict Future Cardiovascular Events in ACS Patients With Intensive Statin Therapy : The Extended JAPAN-ACS Study
- Influence of Achieved Low-Density Lipoprotein Cholesterol Level With Atorvastatin Therapy on Stabilization of Coronary Plaques : Sub-Analysis of the TWINS Study
- Epicardial Ablation With Irrigated Electrodes : Effect of Bipolar vs. Unipolar Ablation on Lesion Formation
- Association Between Epicardial Adipose Tissue Volumes on 3-Dimensional Reconstructed CT Images and Recurrence of Atrial Fibrillation After Catheter Ablation
- Highly Purified Eicosapentaenoic Acid May Increase Low-Density Lipoprotein Particle Size by Improving Triglyceride Metabolism in Patients With Hypertriglyceridemia
- Pulmonary Vein Remnant as a Trigger Site for Atrial Fibrillation
- Impact of Coronary Plaque Burden and Composition on Periprocedural Myocardial Infarction and Coronary Flow Reserve After Percutaneous Coronary Intervention