An Improved Formulation Screening and Optimization Method Applied to the Development of a Self-Microemulsifying Drug Delivery System
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概要
- 論文の詳細を見る
This study focused on the development of an improved formulation screening and optimization method for a self-microemulsifying drug delivery system (SMEDDS). Solubility study and construction of a ternary phase diagram were carried out to determine the primary formulation components. Experimental design combined with a desirability study was employed to obtain the optimal formulation composition. The obtained bufalin SMEDDS formulation was Maisine 35-1 and Miglyol 812N (1 : 1, w/w) of 29.5%, Cremophor EL of 39.5%, and Transcutol P of 30.5%. It showed desired properties with droplet size of 33.9 nm; polydispersity index of 0.126; equilibrium solubility of 12.6 mg/ml, and 73.6% of soluble drug post-digestion. A rapid release of up to 21% occurred in the first 10 min. A bufalin SMEDDS was well absorbed at all intestinal segments. The absorption of bufalin from a SMEDDS was 2.38-fold higher than that of bufalin suspension in terms of relative bioavailability. The studies on solubility and ternary phase diagrams combined with experimental design may offer a valuable and efficient strategy for developing and optimizing a SMEDDS to obtain optimal formulations with desired characteristics.
- 公益社団法人 日本薬学会の論文
著者
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Zhang Xin
Department Of Anatomy Chonbuk National University Medical School:research Center For Allergic Immune
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Chen Zhi
Department Of Elecronic Science And Engineering Kyoto University
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Feng Nian
Department Of Pharmaceutics Shanghai University Of Traditional Chinese Medicine
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Liu Ying
Department Of Anatomy Histology And Embryology Shanghai Medical College Fudan University
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Wu Shan
Department of Pharmaceutics, School of Pharmacy, Shanghai University of Traditional Chinese Medicine
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Zhao Ji
Department of Pharmaceutics, School of Pharmacy, Shanghai University of Traditional Chinese Medicine
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Tan Rong
Department of Pharmaceutics, School of Pharmacy, Shanghai University of Traditional Chinese Medicine
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Zhang Xin
Department of Pharmaceutics, School of Pharmacy, Shanghai University of Traditional Chinese Medicine
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Chen Zhi
Department of Pharmaceutics, School of Pharmacy, Shanghai University of Traditional Chinese Medicine
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