Block Ionomer Complex Micelles Based on the Self-Assembly of Poly(ethylene glycol)-block-poly(acrylic acid) and CdCl2 for Anti-tumor Drug Delivery
スポンサーリンク
概要
- 論文の詳細を見る
A novel block ionomer complex micelles as drug carrier is developed utilizing self-assemble of poly(ethylene glycol)-block-poly(acrylic acid) (PEG-b-PAA) and cadmium chloride. This micelles are characterized to be have good bio-compatibility, hydrophilicity, passive targeting and sustained slow release property which shows great potential for liver cancer therapy. Block ionomer complex micelles based on PEG-b-PAA and cadmium chloride can self-assemble in distilled water, and Cd2+ agent is entrapped into the core stabilized by PEG shells. Results showed the block ionomer complex micelles to be spherically shaped. Cadmium was incorporated easily into the ionic core with remarkably high efficiency (34.25% weight (wt)/wt). The cadmium-loaded polymeric micelles exhibited sustained and slow release behavior of cadmium and a potent cytotoxicity against SMMC-7721 in vitro. This novel block ionomer complex micelles with cores of metal antitumor drug indicates to be potential carriers for effective drug delivery.
著者
-
Ma Ning
Key Laboratory Of Drug Quality Control And Pharmacovigilance Ministry Of Education ; Department Of P
-
Liu Ying
Department Of Dermatology University Of Michigan
-
An Liping
School of Public Health, Jilin University
-
Wang Yapei
Key Laboratory of Organic Optoelectronics and Molecular Engineering, Department of Chemistry, Tsingh
-
Liu Xiaomei
School of Public Health, Jilin University
-
Du Haiying
School of Public Health, Jilin University
-
Jin Minghua
School of Public Health, Jilin University
-
Zhang Long
School of Public Health, Jilin University
-
Xu Yanling
School of Public Health, Jilin University
-
Huang Peili
Department of Toxicology and Sanitary Chemistry, School of Public Health and Family Medicine, Capita
-
Sun Zhiwei
School of Public Health, Jilin University
-
Liu Ying
Department Of Anatomy Histology And Embryology Shanghai Medical College Fudan University
-
Ma Ning
Key Laboratory of Organic Optoelectronics and Molecular Engineering, Department of Chemistry, Tsinghua University
-
Huang Peili
Department of Toxicology and Sanitary Chemistry, School of Public Health and Family Medicine, Capital Medical University
関連論文
- Role of Prehypertension in the Development of Coronary Atherosclerosis in Japan
- Role of Hypertension, Dyslipidemia and Diabetes Mellitus in the Development of Coronary Atherosclerosis in Japan
- Orengedokuto inhibits neointimal formation, proliferation and migration of rat vascular smooth muscle cells in vivo and in vitro
- P2-38 The Protective Effect of Neuregulin-1 to the Oligodendrocyte Progenitor Cells after Acute Injury of the Spinal Cord
- Anticipation of Job Loss or Job Change and Cardiovascular Risk Factors : a Study of Retiring Self-Defense Officials in Japan
- Neuroprotection of catalpol in transient global ischemia in gerbils
- Cortical spreading depression affects Fos expression in the hypothalamic paraventricular nucleus and the cerebral cortex of both hemispheres
- Pathogenicity of Glycoprotein C-Deficient Herpes Simplex Virus 1 Strain TN-1 Which Encodes Truncated Glycoprotein C
- Diagnosis and Treatment of VIPoma in China : (Case Report and 31 Cases Review) Diagnosis and Treatment of VIPoma
- Permeability of injured blood brain barrier for exogenous bFGF and protection mechanism of bFGF in rat brain ischemia
- The protection mechanism of basic fibroblast growth factor in brain ischemia
- Protective role of mouse MBL-C on intestinal mucosa during Shigella flexneri invasion
- Review of animal models for autism : implication of thyroid hormone
- Determination of perospirone by liquid chromatography/electrospray mass spectrometry : Application to a pharmacokinetic study in healthy Chinese volunteers
- UV irradiation induces Snail expression by AP-1 dependent mechanism in human skin keratinocytes
- A Simplified Method to Determine Five Cytochrome P450 Probe Drugs by HPLC in a Single Run(Analytical Biochemistry)
- Quantification of prochlorperazine maleate in human plasma by liquid chromatography-mass spectrometry : Application to a bioequivalence study
- Structural elucidation of in vivo metabolites of penehyclidine in rats by the method of liquid chromatography-mass spectrometry, gas chromatography-mass spectrometry and isotope ion cluster
- Block Ionomer Complex Micelles Based on the Self-Assembly of Poly(ethylene glycol)-block-poly(acrylic acid) and CdCl2 for Anti-tumor Drug Delivery
- A new method to correct Ni- and Cu-argide interference in the determination of the platinum-group elements, Ru, Rh, and Pd, by ICP-MS
- An HPLC method for determination of oridonin in rabbits using isopsoralen as an internal standard and its application to pharmacokinetic studies for oridonin-loaded nanoparticles
- Studies on the Phosphorylation of a M_r 25,000 Portein, a Putative Portein Phosphatase 2A Modulator, by Casein Kinase I, and Analysis of Multiple Endogenous Phosphates^1
- Study on the reference values of serum lipids in children aged 3-18 years old in Beijing, China
- Isolation of 5-hydroxypyrrolidin-2-one and other constituents from the young fronds of Pteridium aquilinum
- THE ROLE OF CLAY IN ELECTRO-RESPONSIVE SMART POLYMER NANOCOMPOSITE MATERIALS
- A novel GATA6 mutation in patients with tetralogy of Fallot or atrial septal defect
- Overexpression of Eg5 predicts unfavorable prognosis in non-muscle invasive bladder urothelial carcinoma
- Common variants of the UMOD promoter associated with blood pressure in a community-based Chinese cohort
- An integrated genomic analysis of gene-function correlation on schizophrenia susceptibility genes
- An Improved Formulation Screening and Optimization Method Applied to the Development of a Self-Microemulsifying Drug Delivery System