Erdosteine in Renal Ischemia-Reperfusion Injury: An Experimental Study in Pigs

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概要

• 論文の詳細を見る

• The aim of the present study was to investigate the effect of erdosteine on renal reperfusion injury. Twelve male Landrace and Yorkshire mixed pigs were randomly divided into two groups: untreated control group (I/R), erdosteine treated group (I/R + erdosteine). Each group is composed of six pigs, and the pigs were unilaterally nephrectomized and their contralateral kidneys were subjected to 30 min of renal pedicle occlusion. The elevations of creatinine and blood urea nitrogen levels were lower in the treated group compared with the control group. The catalase activity and the glutathione peroxidase activity were higher in the erdosteine group. As a result, this study suggests that the erdosteine treatment has a role of attenuation of renal I/R injury recovery of renal function in pig.

• 社団法人　日本獣医学会の論文

著者

• Kim Hyun-soo

  Department Of Internal Medicine Chonnam National University Medical School

• Park Chang-sik

  Division Of Animal Science And Resources Research Center For Transgenic Cloned Pigs Chungnam Nationa

• LEE Jae-Yeon

  Department of Veterinary Surgery, College of Veterinary Medicine, Chungnam National University

• KIM Hyun-Soo

  Veterinary Public Health, College of Veterinary Medicine, Chungnam National University

• KIM Myung-Cheol

  Department of Veterinary Surgery, College of Veterinary Medicine, Chungnam National University

• Kim Hyun-Soo

  Department of Advanced Applied Electronics, Interdisciplinary Graduate School of Science and Engineering, Tokyo Institute of Technology, 4259 Nagatsuta, Midori-ku, Yokohama 226-8502, Japan

• KIM Myung-Cheol

  Department of Veterinary Surgery, Research Center for Transgenic Cloned Pigs, Chungnam National University

• PARK Chang-Sik

  Division of Animal Science & Resources, Research Center for Transgenic Cloned Pigs, Chungnam National University

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