Oxidative Stress More Strongly Induced by ortho- Than para-quinoid Polycyclic Aromatic Hydrocarbons in A549 Cells
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概要
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The effect of four ortho-quinoid polycyclic aromatic hydrocarbons (PAHs) and seven para-quinoid PAHs on the viability of A549 cells were examined. The ortho-quinoid PAHs [1,2-naphthoquinone (1,2-NQ), 9,10-phenanthrenquinone (9,10-PQ), 5,6-chrysenequinone (5,6-CQ), and benzo[c]phenanthrene-5,6-quinone (B[c]P-5,6-Q)] overproduced hydrogen peroxide (H2O2) without being consumed themselves. These ortho-quinoid had strong cytotoxic effects except for 1,2-NQ, since of its tendency to covalently bind to thiol groups. The cytotoxicity appears to be due to the overproduction of H2O2 by ortho-quinoid PAHs in a redox cycle coupled with the consumption of thiol group. In contrast, the para-quinoid PAHs were not as strong cytotoxic and did not produce H2O2.
著者
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Bekki Kanae
Graduate School of Natural Science and Technology, Kanazawa University
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Chung Sang
Graduate School of Natural Science and Technology, Kanazawa University
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Hayakawa Kazuichi
Institute Of Medical Pharmaceutical And Health Sciences Kanazawa University
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Tang Ning
Institute Of Medical Pharmaceutical And Health Sciences Kanazawa University
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Kameda Takayuki
Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University
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Toriba Akira
Institute Of Medical Pharmaceutical And Health Sciences Kanazawa University
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Taguchi Keiko
Department Of Environmental Medicine Doctoral Programs In Medical Sciences Graduate School Of Compre
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Chung Sang
Graduate School Of Natural Sci. And Technol. Kanazawa Univ.
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Motoyama Yumi
Graduate School of Natural Science and Technology, Kanazawa University
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Taguchi Keiko
Department of Medical Biochemistry, Graduate School of Medicine, Tohoku University
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