Isolation, Synthesis, and Bioactivity of Homoisoflavonoids from Caesalpinia pulcherrima

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概要

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• One new homoisoflavonoid, (3E)-2,3-dihydro-6,7-dimethoxy-3[(3-hydroxy-4-methoxyphenyl)methylene]-4H-1-benzopyran-4-one and four naturally new analogues, (3E)-3-(1,3-benzodioxol-5-ylmethylene)-2,3-dihydro-7-hydroxy-4H-1-benzopyran-4-one, (3E)-3-(1,3-benzodioxol-5-ylmethylene)-2,3-dihydro-7-methoxy-4H-1-benzopyran-4-one, (3E)-2,3-dihydro-7-hydroxy-3-[(3-hydroxy-4-methoxyphenyl)methylene]-4H-1-benzopyran-4-one and (3E)-2,3-dihydro-3-[(3,4-dimethoxyphenyl)methylene]-7-methoxy-4H-1-benzopyran-4-one, along with four known homoisoflavonoids, bonducellin, sappanone A, 2′-methoxybonducellin and 7-O-methylbonducellin were isolated from aerial parts of Caesalpinia pulcherrima. The structures of the new compounds were elucidated by interpretation of their 1D and 2D NMR spectra. Syntheses of the naturally new compounds and the known compounds have also been accomplished. The antibacterial and antifungal activities of the isolated homoisoflavonoids were studied.

• 公益社団法人　日本薬学会の論文

著者

• Das Biswanath

  Organic Chemistry Division-i India Institute Of Chemical Technology

• Ravikanth Bommena

  Organic Chemistry Division-i India Institute Of Chemical Technology

• Thirupathi Ponnaboina

  Organic Chemistry Division-I, Indian Institute of Chemical Technology

• Aravind Kumar

  Organic Chemistry Division-I, Indian Institute of Chemical Technology

• Sarma Akella

  NMR Division, Indian Institute of Chemical Technology

• Basha Shaik

  NMR Division, Indian Institute of Chemical Technology

• DAS Biswanath

  Organic Chemistry Division I, Indian Institute of Chemical Technology

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