Synthetic Applications of Baylis-Hillman Chemistry : An Efficient and Solely Stereoselective Synthesis of (E)-α-Methylcinnamic Acids and Potent Hypolipidemic Agent LK-903 from Unmodified Baylis-Hillman Adducts
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概要
- 論文の詳細を見る
An efficient and solely stereoselective synthesis of (E)-α-methylcinnamic acids has been accomplished in single pot by reduction of the unmodified Baylis-Hillman adducts, methyl-3-hydroxy-3-aryl-2-methylene-propanoates with I_2/NaBH_4 reagent system at room temperature followed by hydrolysis. The efficacy of this method has been proved in the total synthesis of 1-[p-(myristyloxy)-α-methylcinnamoyl] glycerol, LK-903, a highly active hypolipidemic agent.
- 公益社団法人日本薬学会の論文
- 2006-12-01
著者
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Banerjee Joydeep
Organic Chemistry Division-i Indian Institute Of Chemical Technology
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Chowdhury Nikhil
Organic Chemistry Division-i India Institute Of Chemical Technology
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Das Biswanath
Organic Chemistry Division‐i Indian Inst. Of Chemical Technol.
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Das Biswanath
Organic Chemistry Division-i India Institute Of Chemical Technology
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MAJHI Anjoy
Organic Chemistry Division-I, Indian Institute of Chemical Technology
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Das Biswanath
Organic Chemistry Division-i Indian Institute Of Chemical Technology
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Majhi Anjoy
Organic Chemistry Division-i India Institute Of Chemical Technology
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Das Biswanath
Organic Chemistry Division-I, Indian Institute of Chemical Technology
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DAS Biswanath
Organic Chemistry Division I, Indian Institute of Chemical Technology
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