First Syntheses of (−)-Tauranin and Antibiotic (−)-BE-40644 Based on Lipase-Catalyzed Optical Resolution of Albicanol

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概要

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• First syntheses of sesquiterpene quinones (−)-tauranin and (−)-BE-40644 which exhibited strong cytotoxicity against several cancer cell lines, were achieved from (8aS)-albicanol obtained by enzymatic optical resolution. By comparison of the sign of specific rotation between synthetic (12bS)-BE-40644 and natural (−)-BE-40644, the absolute configurations of natural (−)-BE-40644 were determined to be 4aS, 6aS, 12aR, 12bS.

• 公益社団法人　日本薬学会の論文

著者

• Fujii Mikio

  Faculty Of Pharmaceutical Sciences Toho University

• Akita Hiroyuki

  Faculty Of Pharmaceutical Sciences Toho University

• Ishii Sadayuki

  Faculty of Pharmaceutical Sciences, Toho University

• Fujii Mikio

  Faculty of Engineering,Tokushima University

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