Polymyositis with Atypical Pathological Features Associated with Thymic Carcinoma
スポンサーリンク
概要
- 論文の詳細を見る
A 66-year-old man was admitted for progressive proximal weakness and myalgia in his shoulder girdles without skin lesions. A muscle biopsy showed infiltration of inflammatory cells, degeneration of muscle fibers, and perifascicular atrophy. Remarkably, MHC-I antigen was expressed in the muscle membrane and most of the inflammatory cells were CD8-positive, suggesting that class-I antigen-dependent cytotoxic T-cells played a crucial role in the muscle pathology, which supported a diagnosis of polymyositis rather than dermatomyositis. Magnetic resonance imaging of his chest revealed two mediastinal tumors, which were extirpated and diagnosed as thymic carcinoma. The muscle weakness was completely recovered after the operation and subsequent administration of oral prednisolone. Postoperative clinical improvement and decline of serum creatinine kinase suggested a paraneoplastic nature of the polymyositis in this patient.
著者
-
Nakagawa Masanori
Department Of Astrophysics Nagoya University
-
Yamaguchi Tatsuyuki
Department Of Cardiovascular Medicine Course Of Medical And Dental Sciences Graduate School Of Biome
-
Shiga Kensuke
Department of Pathology and Applied Neurobiology
-
Yamaguchi Tatsuyuki
Department of Neurology, Kyoto Prefectural University of Medicine
-
Azuma Yumiko
Department of Neurology, Kyoto Prefectural University of Medicine
-
Niwa Fumitoshi
Department of Neurology, Kyoto Prefectural University of Medicine
-
Ishii Ryotaro
Department of Neurology, Kyoto Prefectural University of Medicine
関連論文
- An Immunohistochemical Analysis of Gastric B-cell Lymphomas : Stromal Cells Exhibit Peculiar Histogenesis in Gastric B-cell Lymphomas
- An Unbiased Search for Molecular Clouds in the Southern Galactic Warp
- The Severity of Minamata Disease Declined in 25 Years : Temporal Profile of the Neurological Findings Analyzed by Multiple Logistic Regression Model
- ASSESSMENT OF MITOCHONDRIAL GENE IN PROLIFERATIVE VITREORETINAL TISSUES FROM PATIENTS WITH FAMILIAL DIABETES MELLITUS
- Abiotic factors associated with the occurrence of introduced rainbow trout in the Atsuta River
- A Serine Protease Inhibitor, Nafamostat Mesilate, Suppresses Aldosterone Secretions In Vivo
- Cell permeable ROS scavengers, Tiron and Tempol, rescue PC12 cell death caused by pyrogallol or hypoxia/reoxygenation
- Refinement of a locus for autosomal dominant hereditary motor and sensory neuropathy with proximal dominancy (HMSN-P) and genetic heterogeneity
- Is temporal slow wave on EEG a useful diagnostic tool in vascular depression?
- Proliferative Capacity Persists Most Tenaciously in the Murine Proximal Rostral Migratory Stream
- Inflammatory Myofibroblastic Tumor of the Cerebellar Hemisphere : Case Report
- Improvement of Sleep Hypopnea by Antiparkinsonian Drugs in a Patient with Parkinson's Disease : a Polysomnographic Study
- Structural and Functional Studies on Biliverdin-associated Cyanoprotein from the Bean Bug, Riptortus clavatus
- Subarachnoid Hemorrhage Caused by Pilocytic Astrocytoma : Case Report
- A Commentary on Molecular diagnosis and clinical onset of Charcot-Marie-Tooth disease in Japan
- Polymyositis with Atypical Pathological Features Associated with Thymic Carcinoma
- Two Japanese CADASIL Families Exhibiting Notch3 Mutation R75P Not Involving Cysteine Residue
- Serial MRI changes in a patient with infantile Alexander disease and prolonged survival
- Self-Remitting and Reversible Parkinsonism Associated with Neuro-Sweet Disease