Thrombotic Thrombocytopenic Purpura Complicated with Hypereosinophilic Syndrome
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概要
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An 80-year-old woman was referred to our hospital because of eosinophilia and thrombocytopenia. She presented with persistent pruritus and cough. Laboratory examinations showed persistent eosinophilia, and there was no underlying cause, consistent with hypereosinophilic syndrome (HES). After admission, she developed a neurological deficit, and microangiopathic hemolytic anemia. She was diagnosed with thrombotic thrombocytopenic purpura (TTP) and successfully treated with corticosteroids and plasmapheresis. Although TTP has been described in association with pregnancy, cancer, collagen diseases, infection, and drug intake, hypereosinophilia is not a well-documented cause of this disorder. To our knowledge, this is only the second case of TTP with HES, proved to be caused by ADAMTS13 inhibitor.
著者
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SUGAWARA Tomohiro
Department of Internal Medicine, Osaki Citizen Hospital
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Ohguchi Hiroto
Department Of Hematology And Rheumatology Tohoku University Graduate School Of Medicine
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Sugawara Tomohiro
Department Of Internal Medicine Osaki Citizen Hospital
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Harigae Hideo
Department Of Biochemistry Tohoku University School Of Medicine
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