Aggressive B-Cell Lymphoma with Dual Surface Immunoglobulin Light-Chain Expression
スポンサーリンク
概要
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Dual surface immunoglobulin light-chain expression in B-cell malignant neoplasm is a rare event, and has been predominantly reported in chronic lymphocytic leukemia. Herein, we report a case of aggressive B-cell lymphoma with κ/λ-dual surface immunoglobulin light-chain expression of a 69-year-old woman. The lymphoma cells were positive for CD5, CD19, CD20, HLA-DR, Igκ and Igλ. Southern blot analysis confirmed rearranged bands for both light chains with a monoclonal heavy chain rearrangement. She was treated with a combination of rituximab and CHOP regimen, but died of the progressive disease. To our knowledge, this is the first case of aggressive B-cell lymphoma showing dual κ/λ expression; the possible mechanisms of abnormal light chain expression are discussed.
著者
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Kohata Katsura
Department Of Hematology And Rheumatology Tohoku University Graduate School Of Medicine
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Yamamoto Joji
Department Of Hematology And Rheumatology Tohoku University Graduate School Of Medicine
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Yamada Minami
Department Of Hematology And Rheumatology Tohoku University Hospital
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Fujiwara Tohru
Department Of Clinical Pharmacology And Therapeutics Tohoku University Graduate School Of Medicine A
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Harigae Hideo
Department Of Biochemistry Tohoku University School Of Medicine
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Kameoka Junichi
Department Of Hematology And Rheumatology Tohoku University Graduate School Of Medicine
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HARIGAE HIDEO
Department of Rheumatology and Hematology, Tohoku University Graduate School of Medicine
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ISHIZAWA Kenichi
Hematology and Rheumatology, Tohoku University Graduate School of Medicine
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Yamada Minami
Department of Rheumatology and Hematology, Tohoku University Graduate School of Medicine
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Ishizawa Kenichi
Hematopathology, Tohoku University Graduate School of Medicine
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Ichinohasama Ryo
Hematopathology, Tohoku University Graduate School of Medicine
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Yamamoto Joji
Department of Rheumatology and Hematology, Tohoku University Graduate School of Medicine
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